Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 2/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6648507 | 0.90 | KDM4E (0.53) | KDM4ESMN1; SMN2RAB9ALMNACYP19A1 | |
| SCHEMBL6647162 | 0.87 | KDM4E (0.61) | KDM4ESMN1; SMN2RAB9ALMNACYP19A1 | |
| SCHEMBL6647407 | 0.86 | KDM4E (0.59) | KDM4ESMN1; SMN2RAB9ACYP19A1NPC1 | |
| SCHEMBL6647410 | 0.85 | RAB9A (0.49) | KDM4ESMN1; SMN2RAB9ALMNACYP19A1 | |
| SCHEMBL6628490 | 0.85 | CYP19A1 (0.58) | KDM4ESMN1; SMN2RAB9ALMNACYP19A1 | |
| SCHEMBL6649092 | 0.84 | GAA (0.50) | KDM4ESMN1; SMN2RAB9ALMNACYP19A1 | |
| SCHEMBL6646446 | 0.84 | KDM4E (0.55) | KDM4ESMN1; SMN2RAB9ALMNACYP19A1 | |
| SCHEMBL6649843 | 0.84 | RAB9A (0.60) | KDM4ESMN1; SMN2RAB9ALMNACYP19A1 | |
| SCHEMBL6648609 | 0.82 | CYP19A1 (0.44) | KDM4ESMN1; SMN2RAB9ALMNACYP19A1 | |
| SCHEMBL6648219 | 0.81 | CYP19A1 (0.45) | KDM4ESMN1; SMN2RAB9ALMNACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |