Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | F10 | P00742 | 7/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.45 |
| ▸ | PREP | P48147 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6649287 | 1.00 | NPSR1 (0.56) | NPSR1F10PTPN1HDAC8NR1D1 | |
| SCHEMBL1049445 | 0.86 | NPSR1 (0.63) | NPSR1F10PTPN1HDAC8NR1D1 | |
| SCHEMBL30314166 | 0.85 | NPSR1 (0.62) | NPSR1F10PTPN1 | |
| SCHEMBL29401156 | 0.85 | NPSR1 (0.62) | NPSR1F10PTPN1 | |
| SCHEMBL14862925 | 0.85 | NPSR1 (0.62) | NPSR1F10PTPN1 | |
| SCHEMBL1052393 | 0.85 | NPSR1 (0.62) | NPSR1F10PTPN1 | |
| SCHEMBL3629346 | 0.85 | NPSR1 (0.62) | NPSR1F10PTPN1 | |
| SCHEMBL9252347 | 0.84 | NPSR1 (0.58) | NPSR1F10PTPN1HDAC8NR1D1 | |
| SCHEMBL28564714 | 0.83 | NPSR1 (0.60) | NPSR1F10PTPN1HDAC8PREP | |
| SCHEMBL9591709 | 0.80 | NPSR1 (0.59) | NPSR1F10PTPN1HDAC8PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149079-B1 | TETRAHYDRO ISOQUINO LINEALKANOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SK CORP (KR) | 2004-04-21 | — | — | EP | disclosed |
| EP-1149079-A1 | TETRAHYDRO ISOQUINO LINEALKANOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SK Corporation (KR) | 2001-10-31 | — | — | EP | disclosed |
| WO-2000046204-A1 | TETRAHYDRO ISOQUINO LINEALKANOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SK CORPORATION (KR) | 2000-08-10 | — | — | WO | disclosed |
| US-5955471-A | USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, INCLUDING DEPRESSION | SK CORPORATION (US) | 1999-09-21 | — | — | US | disclosed |