Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF2 | Q12772 | 5/20 | 0.46 |
| ▸ | ATP4A | P20648 | 4/20 | 0.43 |
| ▸ | ATP4B | P51164 | 4/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6649359 | 0.92 | CYP19A1 (0.46) | ATP4AATP4BCYP19A1ALOX5HDAC3 | |
| SCHEMBL6628492 | 0.86 | SREBF2 (0.61) | SREBF2ATP4AATP4BCYP19A1RAB9A | |
| SCHEMBL6628971 | 0.85 | KDM4E (0.51) | SREBF2ATP4AATP4BCYP19A1RAB9A | |
| SCHEMBL6648508 | 0.84 | KDM4E (0.51) | SREBF2CYP19A1RAB9AMAPTKMT2A | |
| SCHEMBL6649838 | 0.83 | KDM4E (0.59) | SREBF2CYP19A1ALOX5RAB9AMAPT | |
| SCHEMBL6649085 | 0.81 | KDM4E (0.59) | SREBF2CYP19A1RAB9AMEN1MAPT | |
| SCHEMBL6649370 | 0.81 | CYP19A1 (0.46) | SREBF2CYP19A1RAB9AMEN1MAPT | |
| SCHEMBL6650443 | 0.81 | SREBF2 (0.55) | SREBF2ATP4AATP4BCYP19A1RAB9A | |
| SCHEMBL6647164 | 0.81 | KDM4E (0.59) | SREBF2ATP4AATP4BCYP19A1RAB9A | |
| SCHEMBL6649374 | 0.81 | SREBF2 (0.59) | SREBF2CYP19A1RAB9AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |