Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 9/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 12/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5641198 | 0.99 | TYK2 (0.48) | TYK2FLT1IKBKBEGFRTUBB4A | |
| SCHEMBL5641499 | 0.78 | NPC1 (0.58) | TYK2FLT1IKBKBEGFRNPC1 | |
| SCHEMBL5789265 | 0.77 | TYK2 (0.51) | TYK2FLT1IKBKBEGFRTUBB4A | |
| SCHEMBL14777324 | 0.77 | FLT1 (0.59) | FLT1EGFRTUBB4ATUBBTUBA3C | |
| SCHEMBL27892410 | 0.75 | EGFR (0.60) | TYK2FLT1EGFRTUBB4ATUBB | |
| SCHEMBL14776871 | 0.75 | EGFR (0.60) | FLT1EGFRTUBB4ATUBBTUBA3C | |
| SCHEMBL7126416 | 0.74 | FLT1 (0.76) | FLT1EGFRKDR | |
| SCHEMBL5641598 | 0.72 | MAPT (0.47) | FLT1NPC1RAB9A | |
| SCHEMBL5641135 | 0.68 | RAB9A (0.68) | IKBKBNPC1RAB9A | |
| SCHEMBL13434839 | 0.66 | FLT1 (0.94) | TYK2FLT1IKBKBEGFRTUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409491-A2 | THIENOPYRIMIDINE-BASED INHIBITORS OF THE SRC FAMILY | Board of Regents, The University of Texas System (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2002057271-A2 | THIENOPYRIMIDINE-BASED INHIBITORS OF THE SRC FAMILY | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2002-07-25 | — | — | WO | disclosed |