Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 19/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629168 | 0.82 | HTR1A (0.82) | HTR1ASLC6A4DRD2CYP3A4CYP2C8 | |
| SCHEMBL4369629 | 0.82 | HTR1A (0.62) | HTR1ASLC6A4DRD2CYP3A4CYP2C8 | |
| SCHEMBL6630467 | 0.82 | HTR1A (0.81) | HTR1ASLC6A4DRD2CYP3A4CYP2C8 | |
| SCHEMBL6903037 | 0.82 | HTR1A (0.76) | HTR1ASLC6A4DRD2CYP3A4CYP2C8 | |
| SCHEMBL4361376 | 0.78 | HTR1A (0.68) | HTR1ASLC6A4DRD2CYP3A4CYP2C8 | |
| SCHEMBL6632051 | 0.77 | HTR1A (0.51) | HTR1ASLC6A4DRD2CYP3A4CYP2C8 | |
| SCHEMBL4363811 | 0.77 | HTR1A (0.66) | HTR1ASLC6A4DRD2CYP3A4CYP2C8 | |
| SCHEMBL6629038 | 0.76 | HTR1A (0.84) | HTR1ASLC6A4DRD2CYP3A4CYP2C8 | |
| SCHEMBL6626807 | 0.76 | HTR1A (0.78) | HTR1ASLC6A4DRD2CYP3A4CYP2C8 | |
| SCHEMBL4363257 | 0.75 | HTR1A (0.73) | HTR1ASLC6A4DRD2CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392697-B1 | ANTIDEPRESSANT AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO 2,3-F]QUINOLINE | WYETH CORP (US) | 2004-11-03 | — | — | EP | claimed |