Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SALL4 | Q9UJQ4 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 6/20 | 0.46 |
| ▸ | TAF1 | P21675 | 1/20 | 0.46 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | GFER | P55789 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | CASP7 | P55210 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6650716 | 0.84 | SALL4 (0.51) | SALL4BRD4TAF1TAF1LTOP2A | |
| SCHEMBL6650382 | 0.84 | GAA (0.58) | TOP2AGAAALDH1A1GFERPOLB | |
| SCHEMBL5168092 | 0.82 | ATM (0.51) | SALL4BRD4GAAALDH1A1KDM4E | |
| SCHEMBL6649470 | 0.80 | BRD4 (0.45) | BRD4TOP2AGAAALDH1A1GFER | |
| SCHEMBL5115847 | 0.80 | SALL4 (0.53) | SALL4BRD4TAF1TAF1LGAA | |
| SCHEMBL5164992 | 0.79 | GAA (0.33) | SALL4BRD4GAAALDH1A1GFER | |
| SCHEMBL5130128 | 0.77 | SALL4 (0.49) | SALL4BRD4TAF1TAF1LGAA | |
| SCHEMBL5164945 | 0.76 | GAA (0.35) | BRD4GAAALDH1A1GFERMEN1 | |
| SCHEMBL5127402 | 0.75 | SALL4 (0.50) | SALL4BRD4TAF1TAF1LTOP2A | |
| SCHEMBL5128134 | 0.74 | BRD4 (0.48) | SALL4BRD4TAF1TAF1LGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326613-B1 | USE OF SUBSTITUTED IMIDAZO 1,2-A]PYRIDINE-, IMIDAZO [1,2-A]PYRIMIDINE AND IMIDAZO [1,2-A]PYRAZINE-3-YL-AMINE DERIVATIVES FOR PRODUCING NOS-INHIBITING MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2004-06-02 | — | — | EP | disclosed |