Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 12/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.33 |
| ▸ | MAPT | P10636 | 8/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.32 |
| ▸ | CASP1 | P29466 | 3/20 | 0.32 |
| ▸ | CASP7 | P55210 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.32 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5164945 | 0.90 | GAA (0.35) | GAAKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL5167941 | 0.86 | PKM (0.39) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL6752274 | 0.85 | MKNK1 (0.39) | GAAKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL6650722 | 0.79 | SALL4 (0.48) | GAAKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL5164942 | 0.76 | MKNK1 (0.36) | GAAKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL5169380 | 0.73 | GAA (0.34) | GAAKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL5168092 | 0.72 | ATM (0.51) | GAAKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL6750698 | 0.71 | RPS6KB2 (0.42) | GAAKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL5167506 | 0.67 | KLK7 (0.40) | GAAKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL5167703 | 0.65 | GAA (0.54) | GAAKDM4EMAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326613-B2 | USE OF SUBSTITUTED IMIDAZO 1,2-A|PYRIDINE-, IMIDAZO ¬1,2-A|PYRIMIDINE AND IMIDAZO ¬1,2-A|PYRAZINE-3-YL-AMINE DERIVATIVES FOR PRODUCING NOS-INHIBITING MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2007-04-18 | — | — | EP | disclosed |
| EP-1326613-B1 | USE OF SUBSTITUTED IMIDAZO 1,2-A]PYRIDINE-, IMIDAZO [1,2-A]PYRIMIDINE AND IMIDAZO [1,2-A]PYRAZINE-3-YL-AMINE DERIVATIVES FOR PRODUCING NOS-INHIBITING MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2004-06-02 | — | — | EP | disclosed |