Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CASR | P41180 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329866 | 1.00 | KDM4E (0.47) | KDM4EBCHEADRB3DNM1KMT2A | |
| SCHEMBL7375804 | 1.00 | KDM4E (0.47) | KDM4EBCHEADRB3DNM1KMT2A | |
| Hydrochloric Acid SCHEMBL6650330 | 0.99 | KDM4E (0.47) | KDM4EBCHEADRB3DNM1KMT2A | |
| SCHEMBL7319894 | 0.93 | KCNH2 (0.43) | BCHEADRB3KMT2AALDH1A1KCNH2 | |
| SCHEMBL7322923 | 0.92 | TP53 (0.47) | ADRB3KMT2AKCNH2ADRB1MEN1 | |
| Hydrochloric Acid SCHEMBL7330275 | 0.91 | TP53 (0.46) | ADRB3KMT2AKCNH2ADRB1MEN1 | |
| Hydrochloric Acid SCHEMBL7372909 | 0.91 | TP53 (0.46) | ADRB3KMT2AKCNH2ADRB1MEN1 | |
| Hydrochloric Acid SCHEMBL7323407 | 0.91 | TP53 (0.46) | ADRB3KMT2AKCNH2ADRB1MEN1 | |
| SCHEMBL7323740 | 0.91 | KCNH2 (0.46) | KDM4EADRB3KMT2AALDH1A1CASR | |
| SCHEMBL7323728 | 0.91 | KCNH2 (0.46) | KDM4EADRB3KMT2AALDH1A1CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647447-B1 | Carbostyril derivatives as phosphodiesterase inhibitors | OTSUKA PHARMA CO LTD (JP) | 2004-05-26 | — | — | EP | claimed |
| US-5532253-A | ENZYME INHIBITORS AS ANTICOAGULANTS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1996-07-02 | — | — | US | claimed |
| EP-0531548-B1 | Carbostyril derivatives as anti-thrombotic agents | OTSUKA PHARMA CO LTD (JP) | 1995-09-27 | — | — | EP | claimed |
| EP-0647447-A1 | Carbostyril derivatives as phosphodiesterase inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-12 | — | — | EP | claimed |
| US-5401754-A | Agent for treating thrombosis and phosphodiesterase inhibitor | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-03-28 | — | — | US | claimed |
| US-5385914-A | Cardiotonic carbostyril agents for treating heart ailments | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-01-31 | — | — | US | claimed |
| EP-0355583-B1 | Cardiotonics | OTSUKA PHARMA CO LTD (JP) | 1995-01-25 | — | — | EP | claimed |
| US-5266577-A | Method of treating congestive heart failure using carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY LTD. (JP) | 1993-11-30 | — | — | US | claimed |
| EP-0531548-A1 | Carbostyril derivatives as anti-thrombotic agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-17 | — | — | EP | claimed |
| US-5053514-A | Side effect reduction; carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1991-10-01 | — | — | US | claimed |
| EP-0355583-A2 | Cardiotonics | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-02-28 | — | — | EP | claimed |
| JP-7285940-A | — | — | None | — | — | JP | disclosed |
| JP-H07285940-A | CARBOSTYRIL DERIVATIVE | OTSUKA PHARMACEUT CO LTD | 1995-10-31 | — | — | JP | disclosed |
| EP-0647447-A1 | Carbostyril derivatives as phosphodiesterase inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |
| US-5385914-A | Cardiotonic carbostyril agents for treating heart ailments | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-01-31 | — | — | US | disclosed |
| EP-0355583-B1 | Cardiotonics | OTSUKA PHARMA CO LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5266577-A | Method of treating congestive heart failure using carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY LTD. (JP) | 1993-11-30 | — | — | US | disclosed |
| US-5198448-A | Cardiovascular disorders | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1993-03-30 | — | — | US | disclosed |
| US-5053514-A | Side effect reduction; carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1991-10-01 | — | — | US | disclosed |
| EP-0355583-A2 | Cardiotonics | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-02-28 | — | — | EP | disclosed |