Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7323407 | 0.99 | TP53 (0.46) | TP53KCNH2ADRB2ADRB1ADRB3 | |
| Hydrochloric Acid SCHEMBL7372909 | 0.99 | TP53 (0.46) | TP53KCNH2ADRB2ADRB1ADRB3 | |
| Hydrochloric Acid SCHEMBL7330275 | 0.99 | TP53 (0.46) | TP53KCNH2ADRB2ADRB1ADRB3 | |
| SCHEMBL7329866 | 0.92 | KDM4E (0.47) | KCNH2ADRB2ADRB1ADRB3KDM1A | |
| SCHEMBL7375804 | 0.92 | KDM4E (0.47) | KCNH2ADRB2ADRB1ADRB3KDM1A | |
| SCHEMBL6650940 | 0.92 | KDM4E (0.47) | KCNH2ADRB2ADRB1ADRB3KDM1A | |
| Hydrochloric Acid SCHEMBL6650330 | 0.91 | KDM4E (0.47) | KCNH2ADRB2ADRB1ADRB3KDM1A | |
| SCHEMBL7319894 | 0.91 | KCNH2 (0.43) | KCNH2ADRB2ADRB1ADRB3KDM1A | |
| Hydrochloric Acid SCHEMBL7329593 | 0.90 | TP53 (0.56) | TP53KCNH2ADRB2ADRB1ADRB3 | |
| SCHEMBL6648856 | 0.88 | LMNA (0.47) | TP53KCNH2ADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0355583-B1 | Cardiotonics | OTSUKA PHARMA CO LTD (JP) | 1995-01-25 | — | — | EP | claimed |
| US-5266577-A | Method of treating congestive heart failure using carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY LTD. (JP) | 1993-11-30 | — | — | US | claimed |
| EP-0355583-A2 | Cardiotonics | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-02-28 | — | — | EP | claimed |