SCHEMBL6651209

SCHEMBL6651209

FC(F)(F)c1ccc(COc2ccc3c(c2)c2c(n3Cc3ccc4ccccc4c3)CNCC2)cc1

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 3/20 0.45
HDAC1 Q13547 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
CYP3A4 P08684 1/20 0.41
S1PR1 P21453 1/20 0.40
MAOB P27338 5/20 0.39
MAOA P21397 4/20 0.39
EGFR P00533 1/20 0.38
IGF1R P08069 1/20 0.38
FLT4 P35916 1/20 0.38
KDR P35968 1/20 0.38
ALOX5AP P20292 4/20 0.38
ALOX5 P09917 1/20 0.37
KDM4E B2RXH2 1/20 0.37
HPGD P15428 1/20 0.37
PPARD Q03181 1/20 0.37
PPARA Q07869 1/20 0.37
PTPN1 P18031 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6651503 0.92 S1PR1 (0.42) MCHR1HDAC1HDAC6CYP3A4S1PR1
SCHEMBL6652167 0.91 MCHR1 (0.48) MCHR1HDAC1HDAC6CYP3A4ALOX5AP
SCHEMBL6650620 0.91 HDAC1 (0.46) MCHR1HDAC1HDAC6CYP3A4MAOB
SCHEMBL6649851 0.89 MCHR1 (0.43) MCHR1HDAC1HDAC6CYP3A4S1PR1
SCHEMBL6646679 0.88 HDAC1 (0.40) MCHR1HDAC1HDAC6CYP3A4MAOB
SCHEMBL6651432 0.88 HDAC6 (0.41) MCHR1HDAC1HDAC6CYP3A4MAOB
SCHEMBL6628574 0.83 PTGS1 (0.46) MCHR1HDAC1HDAC6CYP3A4S1PR1
SCHEMBL6648368 0.82 HTR6 (0.53) HDAC1HDAC6MAOBMAOA
SCHEMBL6651340 0.81 HDAC1 (0.39) MCHR1HDAC1HDAC6CYP3A4IGF1R
SCHEMBL6651066 0.81 S1PR1 (0.42) MCHR1HDAC1HDAC6CYP3A4S1PR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1389194-A2 INHIBITORS OF BACE VERTEX PHARMACEUTICALS INCORPORATED (US) 2004-02-18 EP disclosed
WO-2002088101-A2 INHIBITORS OF BACE VERTEX PHARMACEUTICALS INCORPORATED (US) 2002-11-07 WO disclosed