Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL539175 | 0.88 | PTPN1 (0.64) | PTPN1HDAC8NR1H2NR1H3 | |
| SCHEMBL5204183 | 0.88 | AGTR2 (0.51) | PTPN1PDE4BHDAC8ACEAGTR2 | |
| SCHEMBL7229378 | 0.88 | AGTR2 (0.51) | PTPN1PDE4BHDAC8ACEAGTR2 | |
| SCHEMBL540060 | 0.88 | PTPN1 (0.64) | PTPN1HDAC8NR1H2NR1H3 | |
| SCHEMBL6951953 | 0.85 | PDE4B (0.52) | PTPN1PDE4BPDE4DHDAC8AGTR2 | |
| SCHEMBL19329100 | 0.84 | PTPN1 (0.71) | PTPN1HDAC8 | |
| SCHEMBL7536598 | 0.84 | PTPN1 (0.71) | PTPN1HDAC8 | |
| SCHEMBL1201702 | 0.84 | PTPN1 (0.65) | PTPN1HDAC8 | |
| SCHEMBL23329941 | 0.83 | PTPN1 (0.58) | PTPN1PDE4BPDE4DHDAC8NR1H2 | |
| SCHEMBL539676 | 0.83 | PTPN1 (0.58) | PTPN1HDAC8NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149079-B1 | TETRAHYDRO ISOQUINO LINEALKANOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SK CORP (KR) | 2004-04-21 | — | — | EP | disclosed |
| CN-1142913-C | Tetrahydroisoquinolinealkanol derivatives and pharmaceutical compositions contg. same | SK��ʽ���� | 2004-03-24 | — | — | CN | disclosed |
| CN-1334804-A | Tetrahydroisoquinolinealkanol derivatives and pharmaceutical compositions contg. same | SK CORP (KR) | 2002-02-06 | — | — | CN | disclosed |
| EP-1149079-A1 | TETRAHYDRO ISOQUINO LINEALKANOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SK Corporation (KR) | 2001-10-31 | — | — | EP | disclosed |
| US-6172081-B1 | DIPEPTIDYL PEPTIDASE-IV INHIBITORS; NON-INSULIN DEPENDENT DIABETES | NOVARTIS AG (CH) | 2001-01-09 | — | — | US | disclosed |
| WO-2000046204-A1 | TETRAHYDRO ISOQUINO LINEALKANOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SK CORPORATION (KR) | 2000-08-10 | — | — | WO | disclosed |
| US-5955471-A | USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, INCLUDING DEPRESSION | SK CORPORATION (US) | 1999-09-21 | — | — | US | disclosed |