Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.59 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.49 |
| ▸ | CDC25B | P30305 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6651240 | 0.88 | MAPK13 (0.66) | AKR1C3AKR1C2MEN1KMT2APOLB | |
| SCHEMBL27553444 | 0.85 | AKR1C3 (0.57) | AKR1C3AKR1C2MEN1KMT2APOLB | |
| SCHEMBL27496168 | 0.85 | AKR1C3 (0.56) | AKR1C3AKR1C2MEN1KMT2APOLB | |
| SCHEMBL27498162 | 0.85 | VCAM1 (0.63) | AKR1C3AKR1C2MEN1KMT2APOLB | |
| SCHEMBL27482795 | 0.84 | AKR1C3 (0.55) | AKR1C3AKR1C2MEN1KMT2APOLB | |
| SCHEMBL27497520 | 0.81 | AKR1C3 (0.53) | AKR1C3AKR1C2MEN1KMT2APOLB | |
| SCHEMBL3914644 | 0.81 | MAPK1 (0.71) | AKR1C3AKR1C2MEN1KMT2APOLB | |
| SCHEMBL5981573 | 0.81 | TSHR (0.71) | MEN1KMT2APOLBMAPK1VCAM1 | |
| SCHEMBL27483517 | 0.80 | MAPK13 (0.67) | AKR1C3AKR1C2MEN1KMT2APOLB | |
| SCHEMBL6678800 | 0.80 | MAPK13 (0.66) | AKR1C3AKR1C2MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1188388-C | Aminobenzophenones as inhibitors of interleukin and TNF | LEO PHARM PROD LTD (DK) | 2005-02-09 | — | — | CN | disclosed |
| EP-0966424-B1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | LEO PHARMA AS (DK) | 2004-06-23 | — | — | EP | disclosed |
| US-6313174-B1 | FOR THERAPY AND PROPHYLAXIS OF ASTHMA, ALLERGY, RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, GOUT, ATHEROSCLEROSIS, CHRONIC INFLAMMATORY BOWEL DISEASE, PROLIFERATIVE AND INFLAMMATORY SKIN DISORDERS | Leo Pharmaceutical Products Ltd.A/S/ (Løvens kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-11-06 | — | — | US | disclosed |