SCHEMBL6651455

SCHEMBL6651455

CCCCCCOc1ccc(-c2ccc(O)cc2)nc1F

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.49
RAB9A P51151 2/20 0.49
ATM Q13315 2/20 0.49
MAPT P10636 1/20 0.49
STAT3 P40763 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
NR5A1 Q13285 1/20 0.49
LTA4H P09960 2/20 0.43
PTPN11 Q06124 4/20 0.41
KDM4E B2RXH2 2/20 0.40
ALDH1A1 P00352 2/20 0.40
HPGD P15428 2/20 0.40
HTT P42858 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
ESR1 P03372 3/20 0.40
TLR8 Q9NR97 1/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
CYSLTR2 Q9NS75 1/20 0.38
CYSLTR1 Q9Y271 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8026681 1.00 NPC1 (0.49) NPC1RAB9AATMMAPTSTAT3
SCHEMBL6863382 0.88 KDM4E (0.53) NPC1RAB9AMAPTSMN1; SMN2NR5A1
SCHEMBL9140257 0.88 KDM4E (0.53) NPC1RAB9AMAPTSMN1; SMN2NR5A1
SCHEMBL9138896 0.88 KDM4E (0.53) NPC1RAB9AMAPTSMN1; SMN2NR5A1
SCHEMBL8504280 0.86 KDM4E (0.52) NPC1RAB9AMAPTSMN1; SMN2NR5A1
SCHEMBL8504583 0.84 MAPT (0.47) NPC1RAB9AATMMAPTSTAT3
SCHEMBL8504291 0.84 MAPT (0.47) NPC1RAB9AATMMAPTSTAT3
SCHEMBL8038453 0.82 HRH3 (0.47) NPC1RAB9AMAPTSMN1; SMN2LTA4H
SCHEMBL8042543 0.81 ALDH1A1 (0.47) NPC1RAB9AMAPTSMN1; SMN2NR5A1
SCHEMBL8506788 0.81 KDM4E (0.43) MAPTNR5A1PTPN11KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1147162-B1 FERROELECTRIC ACTIVE MATRIX DISPLAYS WITH WIDE OPERATING TEMPERATURE RANGE CLARIANT GMBH (DE) 2004-06-09 EP disclosed
US-6746731-B1 ACHIEVES VERY HIGH MAXIMUM TRANSMISSION AND VERY HIGH CONTRAST AND CONSTANT THRESHOLD VOLTAGE OVER BROAD TEMPERATURE RANGE CLARIANT GMBH (DE) 2004-06-08 US disclosed
EP-1147162-A1 FERROELECTRIC ACTIVE MATRIX DISPLAYS WITH WIDE OPERATING TEMPERATURE RANGE Clariant GmbH (DE) 2001-10-24 EP disclosed
WO-2000036054-A1 FERROELECTRIC ACTIVE MATRIX DISPLAYS WITH WIDE OPERATING TEMPERATURE RANGE CLARIANT GMBH (DE) 2000-06-22 WO disclosed