Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8125732 | 1.00 | SOAT1 (0.53) | SOAT1SMN1; SMN2ESR1ESR2HSD11B1 | |
| SCHEMBL6651637 | 1.00 | SOAT1 (0.53) | SOAT1SMN1; SMN2ESR1ESR2HSD11B1 | |
| SCHEMBL14440738 | 0.83 | ALDH1A1 (0.53) | SOAT1SMN1; SMN2HSD11B1P2RX3ALDH1A1 | |
| SCHEMBL5448047 | 0.83 | ALDH1A1 (0.53) | SOAT1SMN1; SMN2HSD11B1P2RX3ALDH1A1 | |
| SCHEMBL4172908 | 0.83 | MEN1 (0.53) | SOAT1SMN1; SMN2HSD11B1P2RX3ALDH1A1 | |
| SCHEMBL4172905 | 0.83 | MEN1 (0.53) | SOAT1SMN1; SMN2HSD11B1P2RX3ALDH1A1 | |
| SCHEMBL4172914 | 0.83 | MEN1 (0.53) | SOAT1SMN1; SMN2HSD11B1P2RX3ALDH1A1 | |
| SCHEMBL15841483 | 0.83 | SMN1; SMN2 (0.47) | SOAT1SMN1; SMN2ESR1ESR2HSD11B1 | |
| SCHEMBL9280098 | 0.83 | ESR1 (0.69) | SOAT1SMN1; SMN2ESR1ESR2HSD11B1 | |
| SCHEMBL4168315 | 0.82 | SMN1; SMN2 (0.43) | SOAT1SMN1; SMN2HSD11B1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0552041-B1 | Enzymatic processes for resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes | SQUIBB & SONS INC (US) | 2000-08-30 | — | — | EP | claimed |
| US-5567614-A | ANTICANCER AGENTS | E.R. SQUIBB & SONS, INC. (US) | 1996-10-22 | — | — | US | claimed |
| EP-1001036-B1 | Enzymatic processes for resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes | SQUIBB & SONS INC (US) | 2004-10-20 | — | — | EP | disclosed |
| US-20010037020-A1 | Method for preparation of taxol | HOLTON ROBERT H (US) | 2001-11-01 | — | — | US | disclosed |
| EP-0552041-B1 | Enzymatic processes for resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes | SQUIBB & SONS INC (US) | 2000-08-30 | — | — | EP | disclosed |
| EP-1001036-A2 | Enzymatic processes for resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes | E.R. Squibb & Sons, Inc. (US) | 2000-05-17 | — | — | EP | disclosed |
| US-6008347-A | N-substituted 2-azetidinones | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-28 | — | — | US | disclosed |
| US-5811292-A | CONTACTING MIXTURE OF ENANTIOMERS WITH VINYL ACETATE AND WITH LIPASE ENZYME WHICH CATALYZES STEREOSPECIFIC ESTERIFICATION OF MIXTURE | E. R. SQUIBB & SONS, INC. (US) | 1998-09-22 | — | — | US | disclosed |
| EP-0400971-B1 | Method for preparation of taxol | UNIV FLORIDA STATE (US) | 1998-07-29 | — | — | EP | disclosed |
| US-5574156-A | N-CARBONYL AZETIDIN-2-ONES | FLORIDA STATE UNIVERSITY (US) | 1996-11-12 | — | — | US | disclosed |
| US-5567614-A | ANTICANCER AGENTS | E.R. SQUIBB & SONS, INC. (US) | 1996-10-22 | — | — | US | disclosed |
| EP-0627418-A1 | N-subtituted 2-azetidinones and processes for the production of N-unsubstituted 2-azetidinones therefrom | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-12-07 | — | — | EP | disclosed |
| US-5336785-A | Reacting a beta-lactam with an alcohol to form a taxol intermediate | FLORIDA STATE UNIVERSITY (US) | 1994-08-09 | — | — | US | disclosed |
| EP-0582469-A2 | Process for preparing taxol-type compound from beta-lactam precursors | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1994-02-09 | — | — | EP | disclosed |
| EP-0552041-A2 | Enzymatic processes for resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes | E.R. Squibb & Sons, Inc. (US) | 1993-07-21 | — | — | EP | disclosed |
| US-5175315-A | Reacting with alcohol in presence of altivating agent | FLORIDA STATE UNIVERSITY (US) | 1992-12-29 | — | — | US | disclosed |
| US-5136060-A | Reacting with alcohol | FLORIDA STATE UNIVERSITY (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0428376-A1 | Method for preparation of taxol using an oxazinone | FLORIDA STATE UNIVERSITY (US) | 1991-05-22 | — | — | EP | disclosed |
| US-5015744-A | Esterification of an alcohol with an oxazinone | FLORIDA STATE UNIVERSITY (US) | 1991-05-14 | — | — | US | disclosed |
| EP-0400971-A2 | Method for preparation of taxol | FLORIDA STATE UNIVERSITY (US) | 1990-12-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010037020-A1 | Method for preparation of taxol | TUBA1A, TUBB1, TOP1 | SOAT1 687/4885SMN1; SMN2 784/4885ESR1 2218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.