Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.69 |
| ▸ | IGF1R | P08069 | 2/20 | 0.69 |
| ▸ | NAT1 | P18440 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.65 |
| ▸ | PIM1 | P11309 | 6/20 | 0.64 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.64 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.64 |
| ▸ | GSK3B | P49841 | 2/20 | 0.63 |
| ▸ | TDP2 | O95551 | 1/20 | 0.61 |
| ▸ | CASP7 | P55210 | 1/20 | 0.61 |
| ▸ | CASP9 | P55211 | 1/20 | 0.61 |
| ▸ | CASP6 | P55212 | 1/20 | 0.61 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6651680 | 1.00 | TTR (0.69) | TTRIGF1RNAT1MEN1KMT2A | |
| SCHEMBL14564270 | 0.81 | NAT1 (1.00) | TTRIGF1RNAT1MEN1KMT2A | |
| SCHEMBL1250147 | 0.81 | TTR (0.67) | TTRIGF1RNAT1MEN1KMT2A | |
| SCHEMBL3939871 | 0.81 | TTR (0.67) | TTRIGF1RNAT1MEN1KMT2A | |
| SCHEMBL7464188 | 0.81 | TTR (1.00) | TTRIGF1RNAT1MEN1KMT2A | |
| SCHEMBL7456375 | 0.81 | IGF1R (1.00) | TTRIGF1RNAT1MEN1KMT2A | |
| SCHEMBL1249158 | 0.81 | NAT1 (1.00) | TTRIGF1RNAT1MEN1KMT2A | |
| SCHEMBL13724876 | 0.81 | TTR (1.00) | TTRIGF1RNAT1MEN1KMT2A | |
| SCHEMBL3939868 | 0.81 | TTR (0.67) | TTRIGF1RNAT1MEN1KMT2A | |
| SCHEMBL1249157 | 0.81 | NAT1 (1.00) | TTRIGF1RNAT1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189583-A4 | INDOLE DERIVATIVES | NEURIM PHARMA 1991 (IL) | 2004-04-14 | — | — | EP | claimed |
| EP-1189583-A1 | INDOLE DERIVATIVES | NEURIM PHARMACEUTICALS (1991) LIMITED (IL) | 2002-03-27 | — | — | EP | claimed |
| WO-2000072815-A1 | INDOLE DERIVATIVES | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2000-12-07 | — | — | WO | claimed |