SCHEMBL6651964

SCHEMBL6651964

Cc1ccc(C2=CCNC(CCCc3nc4c(c(=O)[nH]3)CSCC4)C2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 11/20 0.42
PARP3 Q9Y6F1 2/20 0.42
PARP15 Q460N3 1/20 0.42
TNKS2 Q9H2K2 7/20 0.42
TNKS O95271 6/20 0.42
WNT3A P56704 2/20 0.40
PARP2 Q9UGN5 2/20 0.40
PARP14 Q460N5 1/20 0.40
PARP4 Q9UKK3 1/20 0.40
AXIN2 Q9Y2T1 1/20 0.40
BCHE P06276 1/20 0.32
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
HPGD P15428 1/20 0.31
CYP2C19 P33261 1/20 0.31
MMP13 P45452 1/20 0.31
HTR2C P28335 1/20 0.30
NPC1 O15118 1/20 0.30
MAPT P10636 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6418477 0.91 PARP1 (0.43) PARP1PARP3PARP15TNKS2TNKS
SCHEMBL6647363 0.91 PARP1 (0.42) PARP1PARP3PARP15TNKS2TNKS
SCHEMBL6649328 0.91 PARP1 (0.44) PARP1PARP3PARP15TNKS2TNKS
SCHEMBL6647352 0.90 TNKS2 (0.47) PARP1PARP3PARP15TNKS2TNKS
SCHEMBL6651974 0.88 TNKS (0.39) PARP1PARP3PARP15TNKS2TNKS
SCHEMBL6373244 0.77 PARP1 (0.64) PARP1PARP2
SCHEMBL6646707 0.77 PARP1 (0.58) PARP1TNKS2TNKSHPGDHTR2C
SCHEMBL6648890 0.77 PARP1 (0.56) PARP1TNKS2TNKSHPGDHTR2C
Hydrochloric Acid SCHEMBL6647300 0.75 TNKS (0.39) PARP1PARP3PARP15TNKS2TNKS
SCHEMBL6651055 0.75 PARP1 (0.45) PARP1TNKS2TNKSHTR2CMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1469854-A1 CONDENSED HETEROCYCLIC COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-10-27 EP disclosed
WO-2003063874-A1 CONDENSED HETEROCYCLIC COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2003-08-07 WO disclosed