Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 3/20 | 0.80 |
| ▸ | CTSL | P07711 | 3/20 | 0.80 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.67 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | MYC | P01106 | 1/20 | 0.60 |
| ▸ | MAX | P61244 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 2/20 | 0.58 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.56 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.56 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.56 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL354532 | 0.89 | CTSV (1.00) | CTSVCTSLAKR1C3AKR1C2MAPT | |
| SCHEMBL4249101 | 0.88 | CTSV (0.86) | CTSVCTSLAKR1C3AKR1C2MAPT | |
| SCHEMBL6657520 | 0.85 | CTSV (0.56) | CTSVCTSLAKR1C3AKR1C2MAPT | |
| SCHEMBL5174834 | 0.85 | MAPT (0.75) | CTSVCTSLAKR1C3AKR1C2MAPT | |
| SCHEMBL7875188 | 0.85 | CTSV (0.56) | CTSVCTSLAKR1C3AKR1C2MAPT | |
| SCHEMBL27482793 | 0.84 | CTSV (0.71) | CTSVCTSLAKR1C3AKR1C2MAPT | |
| SCHEMBL6484456 | 0.84 | CTSV (0.78) | CTSVCTSLAKR1C3AKR1C2MAPT | |
| SCHEMBL3030579 | 0.83 | CTSV (0.77) | CTSVCTSLAKR1C3AKR1C2MAPT | |
| SCHEMBL14069980 | 0.83 | CTSV (0.77) | CTSVCTSLAKR1C3AKR1C2MAPT | |
| SCHEMBL7331642 | 0.83 | CTSV (0.77) | CTSVCTSLAKR1C3AKR1C2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966424-B1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | LEO PHARMA AS (DK) | 2004-06-23 | — | — | EP | disclosed |
| US-6313174-B1 | FOR THERAPY AND PROPHYLAXIS OF ASTHMA, ALLERGY, RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, GOUT, ATHEROSCLEROSIS, CHRONIC INFLAMMATORY BOWEL DISEASE, PROLIFERATIVE AND INFLAMMATORY SKIN DISORDERS | Leo Pharmaceutical Products Ltd.A/S/ (Løvens kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-11-06 | — | — | US | disclosed |