Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | SCN1A | P35498 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30997262 | 0.88 | HRH3 (0.61) | DRD3HRH3HRH1KDM4E | |
| SCHEMBL9825515 | 0.86 | DRD3 (0.66) | DRD3HRH3HTR2AHRH1 | |
| SCHEMBL19689597 | 0.85 | DRD3 (0.58) | DRD3HRH3HRH1 | |
| SCHEMBL9826117 | 0.84 | DRD3 (0.76) | DRD3HRH3MAPK1CYP1A2HTR2A | |
| SCHEMBL30979868 | 0.81 | HRH3 (0.54) | FGFR1SRCHRH3ALDH1A1MAPK1 | |
| SCHEMBL29464187 | 0.81 | DRD3 (0.62) | DRD3HRH3HRH1 | |
| SCHEMBL29464188 | 0.81 | DRD3 (0.62) | DRD3HRH3HRH1 | |
| SCHEMBL3067381 | 0.81 | HRH3 (0.54) | FGFR1SRCHRH3ALDH1A1MAPK1 | |
| SCHEMBL9825963 | 0.81 | SLC6A4 (0.73) | DRD3HRH3HTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL9826980 | 0.80 | SLC6A4 (0.71) | DRD3HRH3HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-A1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | ELI LILLY AND COMPANY (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002094833-A1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | ELI LILLY AND COMPANY (US) | 2002-11-28 | — | — | WO | disclosed |