Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6728975 | 0.99 | HRH3 (0.47) | HRH3KDM4ERECQLTDP1KDM1A | |
| SCHEMBL6648923 | 0.88 | HRH3 (0.46) | HRH3KDM4ERECQLTDP1KDM1A | |
| SCHEMBL6652158 | 0.88 | HRH3 (0.51) | HRH3KDM4ERECQLTDP1KDM1A | |
| Hydrochloric Acid SCHEMBL6725728 | 0.87 | HRH3 (0.46) | HRH3KDM4ERECQLTDP1KDM1A | |
| Hydrochloric Acid SCHEMBL6728490 | 0.87 | HRH3 (0.50) | HRH3KDM4ERECQLTDP1KDM1A | |
| SCHEMBL7823916 | 0.84 | HRH3 (0.55) | HRH3KDM1ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL6725941 | 0.83 | HRH3 (0.54) | HRH3KDM1ASIGMAR1 | |
| SCHEMBL7821188 | 0.81 | HRH3 (0.53) | HRH3KDM4ERECQLTDP1USP2 | |
| Hydrochloric Acid SCHEMBL8055682 | 0.80 | HRH3 (0.52) | HRH3KDM4ERECQLTDP1USP2 | |
| SCHEMBL7816469 | 0.77 | HRH3 (0.57) | HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143971-B1 | SUBSTITUTED 1-(PIPERIDIN-4-YL)-3-(ARYL)-ISOTHIOUREAS, THEIR PREPARATION AND THERAPEUTIC USE | PF MEDICAMENT (FR) | 2004-06-02 | — | — | EP | disclosed |
| EP-1143971-A1 | SUBSTITUTED 1-(PIPERIDIN-4-YL)-3-(ARYL)-ISOTHIOUREAS, THEIR PREPARATION AND THERAPEUTIC USE | PIERRE FABRE MEDICAMENT (FR) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000043011-A1 | SUBSTITUTED 1-(PIPERIDIN-4-YL)-3-(ARYL)-ISOTHIOUREAS, THEIR PREPARATION AND THERAPEUTIC USE | PIERRE FABRE MEDICAMENT (FR) | 2000-07-27 | — | — | WO | disclosed |