Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | HRH2 | P25021 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6725941 | 0.99 | HRH3 (0.54) | HRH3HRH4HRH2HRH1SIGMAR1 | |
| SCHEMBL6652158 | 0.96 | HRH3 (0.51) | HRH3HRH4HRH2HRH1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6728490 | 0.95 | HRH3 (0.50) | HRH3HRH4HRH2HRH1SIGMAR1 | |
| SCHEMBL7819491 | 0.85 | HRH3 (0.62) | HRH3HRH2HRH1SIGMAR1HTR1A | |
| Hydrochloric Acid SCHEMBL8042992 | 0.84 | HRH3 (0.60) | HRH3HRH2HRH1SIGMAR1HTR1A | |
| SCHEMBL6652553 | 0.84 | HRH3 (0.48) | HRH3SIGMAR1KDM1A | |
| Hydrochloric Acid SCHEMBL6728975 | 0.83 | HRH3 (0.47) | HRH3SIGMAR1KDM1A | |
| SCHEMBL7816469 | 0.83 | HRH3 (0.57) | HRH3HRH4HRH2HRH1SIGMAR1 | |
| SCHEMBL19692566 | 0.83 | SIGMAR1 (0.72) | HRH3HRH2HRH1SIGMAR1HTR1A | |
| SCHEMBL6648923 | 0.82 | HRH3 (0.46) | HRH3SIGMAR1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842174-B1 | HETEROCYCLIC COMPOUNDS FOR TREATING MYOCARDIAL ISCHAEMIA | PF MEDICAMENT (FR) | 2001-10-04 | — | — | EP | disclosed |
| US-6011032-A | Heterocyclic compounds for treating myocardial ischemia | PIERRE FABRE MEDICAMENT (FR) | 2000-01-04 | — | — | US | disclosed |