Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 13/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9755390 | 0.86 | TOP2A (0.55) | KDM1APOLBRAD52KMT2AL3MBTL1 | |
| SCHEMBL93697 | 0.81 | KDM1A (0.54) | KDM1AKMT2ANPSR1 | |
| SCHEMBL27680069 | 0.79 | KDM1A (0.46) | KDM1AKDM4EPOLBMAPTOPRM1 | |
| SCHEMBL29034513 | 0.77 | ALDH1A1 (0.46) | KDM4EPOLBMAPTKMT2A | |
| SCHEMBL27961728 | 0.76 | ALDH1A1 (0.45) | KDM4EPOLBMAPTKMT2AL3MBTL1 | |
| SCHEMBL9755413 | 0.76 | TOP2A (0.50) | KDM1APOLBRAD52KMT2A | |
| SCHEMBL29562242 | 0.75 | ALDH1A1 (0.55) | KDM1AKDM4EPOLBMAPTKMT2A | |
| SCHEMBL28201815 | 0.75 | ALDH1A1 (0.55) | KDM1AKDM4EPOLBMAPTKMT2A | |
| SCHEMBL9755333 | 0.73 | KDM1A (0.51) | KDM1APOLBRAD52KMT2A | |
| SCHEMBL9755327 | 0.73 | POLB (0.50) | KDM1AKDM4EPOLBMAPTOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478645-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | Amgen Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003066630-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | AMGEN INC. (US) | 2003-08-14 | — | — | WO | disclosed |