SCHEMBL6652963

SCHEMBL6652963

Cc1ccccc1C(=O)c1ccc(Nc2ccccc2NC(=O)C(F)(F)F)cc1Cl

nearest known ligand 0.76

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 15/20 0.76
MAPK13 O15264 14/20 0.76
MAPK12 P53778 14/20 0.76
MAPK11 Q15759 14/20 0.76
AVPR2 P30518 1/20 0.44
OXTR P30559 1/20 0.44
AVPR1A P37288 1/20 0.44
TAS2R14 Q9NYV8 1/20 0.44
DHODH Q02127 1/20 0.43
LMNA P02545 1/20 0.41
POLB P06746 1/20 0.41
MAPT P10636 1/20 0.41
GRM4 Q14833 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2201657 0.91 MAPK14 (0.74) MAPK14MAPK13MAPK12MAPK11AVPR2
SCHEMBL6905240 0.90 MAPK14 (0.68) MAPK14MAPK13MAPK12MAPK11AVPR2
SCHEMBL6651799 0.87 MAPK14 (0.84) MAPK14MAPK13MAPK12MAPK11AVPR2
SCHEMBL7642695 0.86 MAPK14 (1.00) MAPK14MAPK13MAPK12MAPK11DHODH
SCHEMBL1904637 0.84 MAPK14 (1.00) MAPK14MAPK13MAPK12MAPK11AVPR2
SCHEMBL27497514 0.84 MAPK14 (0.76) MAPK14MAPK13MAPK12MAPK11AVPR2
SCHEMBL6824435 0.84 MAPK14 (0.79) MAPK14MAPK13MAPK12MAPK11AVPR2
SCHEMBL1907370 0.84 MAPK14 (0.76) MAPK14MAPK13MAPK12MAPK11AVPR2
SCHEMBL6824404 0.83 MAPK14 (0.74) MAPK14MAPK13MAPK12MAPK11AVPR2
SCHEMBL1906421 0.83 MAPK14 (0.87) MAPK14MAPK13MAPK12MAPK11AVPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1202957-B1 AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA LEO PHARMA AS (DK) 2004-09-29 EP claimed
EP-0966424-B1 AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF LEO PHARMA AS (DK) 2004-06-23 EP claimed
EP-1202954-B1 NOVEL AMINOBENZOPHENONES LEO PHARMA AS (DK) 2003-10-01 EP claimed
US-6624199-B1 Prophylaxis and treatment of acne and acne related skin diseases with aminobenzophenones, and novel compounds effective in the treatment, as well as pharmaceutical preparations containing these compounds and dosage units LEO PHARMACEUTICALS PRODUCTS LTD. A/S (DK) 2003-09-23 US claimed
US-6555710-B1 Derivatives of 2,2,2-trifluoro-N-2-(benzoylphenylaminophenyl acetamide; antiinflammatory agents, suppression of interleukin (IL)-beta and tumor necrosis factor (TNF)-alpha; antiarthritic, anticholinergic agents; asthma; antiallergens LEO PHARMACEUTICAL PRODUCTS LTD A/S LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB (DK) 2003-04-29 US claimed
US-6313174-B1 FOR THERAPY AND PROPHYLAXIS OF ASTHMA, ALLERGY, RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, GOUT, ATHEROSCLEROSIS, CHRONIC INFLAMMATORY BOWEL DISEASE, PROLIFERATIVE AND INFLAMMATORY SKIN DISORDERS Leo Pharmaceutical Products Ltd.A/S/ (Løvens kemiske Fabrik Produktionsaktieselskab) (DK) 2001-11-06 US claimed
EP-0966424-A1 AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) 1999-12-29 EP claimed
WO-1998032730-A1 AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 1998-07-30 WO claimed
EP-1202957-B1 AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA LEO PHARMA AS (DK) 2004-09-29 EP disclosed
EP-1202957-B1 AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA LEO PHARMA AS (DK) 2004-09-29 EP disclosed
EP-0966424-B1 AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF LEO PHARMA AS (DK) 2004-06-23 EP disclosed
EP-1202954-B1 NOVEL AMINOBENZOPHENONES LEO PHARMA AS (DK) 2003-10-01 EP disclosed
US-6624199-B1 Prophylaxis and treatment of acne and acne related skin diseases with aminobenzophenones, and novel compounds effective in the treatment, as well as pharmaceutical preparations containing these compounds and dosage units LEO PHARMACEUTICALS PRODUCTS LTD. A/S (DK) 2003-09-23 US disclosed
US-6555710-B1 Derivatives of 2,2,2-trifluoro-N-2-(benzoylphenylaminophenyl acetamide; antiinflammatory agents, suppression of interleukin (IL)-beta and tumor necrosis factor (TNF)-alpha; antiarthritic, anticholinergic agents; asthma; antiallergens LEO PHARMACEUTICAL PRODUCTS LTD A/S LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB (DK) 2003-04-29 US disclosed
EP-1202954-A1 NOVEL AMINOBENZOPHENONES LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) 2002-05-08 EP disclosed
US-6313174-B1 FOR THERAPY AND PROPHYLAXIS OF ASTHMA, ALLERGY, RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, GOUT, ATHEROSCLEROSIS, CHRONIC INFLAMMATORY BOWEL DISEASE, PROLIFERATIVE AND INFLAMMATORY SKIN DISORDERS Leo Pharmaceutical Products Ltd.A/S/ (Løvens kemiske Fabrik Produktionsaktieselskab) (DK) 2001-11-06 US disclosed
WO-2001005745-A1 AMINOBENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 2001-01-25 WO disclosed
WO-2001005744-A1 NOVEL AMINOBENZOPHENONES Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 2001-01-25 WO disclosed
EP-0966424-A1 AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) 1999-12-29 EP disclosed
WO-1998032730-A1 AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 1998-07-30 WO disclosed