SCHEMBL6824404

SCHEMBL6824404

Cc1ccccc1C(=O)c1ccc(Nc2ccccc2NC(=O)NC(C)(C)C)cc1Cl

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 14/20 0.74
MAPK13 O15264 13/20 0.74
MAPK12 P53778 13/20 0.74
MAPK11 Q15759 13/20 0.74
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
MAPK1 P28482 1/20 0.46
HTT P42858 1/20 0.44
DHODH Q02127 1/20 0.42
AVPR2 P30518 1/20 0.41
OXTR P30559 1/20 0.41
AVPR1A P37288 1/20 0.41
KDM4E B2RXH2 1/20 0.40
NPC1 O15118 1/20 0.40
ALDH1A1 P00352 1/20 0.40
MAPT P10636 1/20 0.40
NFKB1 P19838 1/20 0.40
RAB9A P51151 1/20 0.40
GFER P55789 1/20 0.40
NFKB2 Q00653 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6824435 0.88 MAPK14 (0.79) MAPK14MAPK13MAPK12MAPK11MEN1
SCHEMBL6824979 0.87 MAPK14 (0.77) MAPK14MAPK13MAPK12MAPK11MEN1
SCHEMBL6651799 0.86 MAPK14 (0.84) MAPK14MAPK13MAPK12MAPK11MEN1
SCHEMBL7642695 0.85 MAPK14 (1.00) MAPK14MAPK13MAPK12MAPK11KMT2A
SCHEMBL6827035 0.85 MAPK14 (1.00) MAPK14MAPK13MAPK12MAPK11DHODH
SCHEMBL6824421 0.85 MAPK14 (0.74) MAPK14MAPK13MAPK12MAPK11MEN1
SCHEMBL1904637 0.84 MAPK14 (1.00) MAPK14MAPK13MAPK12MAPK11DHODH
SCHEMBL6652963 0.83 MAPK14 (0.76) MAPK14MAPK13MAPK12MAPK11DHODH
SCHEMBL6824447 0.83 MAPK14 (0.69) MAPK14MAPK13MAPK12MAPK11
SCHEMBL6821196 0.83 MAPK14 (0.84) MAPK14MAPK13MAPK12MAPK11MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1210325-B1 AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA LEO PHARMA AS (DK) 2004-10-06 EP disclosed
US-6750253-B1 INHIBITION OR DOWN REGULATION OF THE CYTOKINES IS POSSIBLY DUE TO AN INHIBITION OF MAP KINASES LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) 2004-06-15 US disclosed
EP-1210325-A1 AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) 2002-06-05 EP disclosed
WO-2001005751-A1 AMINOBENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 2001-01-25 WO disclosed