Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.68 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.60 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.59 |
| ▸ | ESRRG | P62508 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10946728 | 0.89 | SRD5A2 (0.83) | SRD5A2EPHX2SIRT1RAB9AALDH1A1 | |
| SCHEMBL1148445 | 0.89 | SRD5A2 (0.83) | SRD5A2EPHX2SIRT1RAB9AALDH1A1 | |
| SCHEMBL8762167 | 0.88 | SRD5A2 (0.52) | SRD5A2EPHX2SIRT1ESRRGRAB9A | |
| Hydrochloric Acid SCHEMBL27713186 | 0.87 | SRD5A2 (0.79) | SRD5A2EPHX2SIRT1RAB9AALDH1A1 | |
| SCHEMBL10628381 | 0.83 | SRD5A2 (0.47) | SRD5A2EPHX2SIRT1ESRRGRAB9A | |
| SCHEMBL20148804 | 0.83 | SRD5A2 (0.73) | SRD5A2EPHX2SIRT1RAB9AALDH1A1 | |
| SCHEMBL12551369 | 0.83 | SRD5A2 (0.73) | SRD5A2EPHX2SIRT1RAB9AALDH1A1 | |
| SCHEMBL12451655 | 0.83 | SRD5A2 (0.73) | SRD5A2EPHX2SIRT1RAB9AALDH1A1 | |
| SCHEMBL33319 | 0.82 | RAB9A (0.73) | EPHX2ESRRGRAB9AALDH1A1NPC1 | |
| SCHEMBL62657 | 0.82 | CA12 (0.59) | SRD5A2RAB9AALDH1A1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966424-B1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | LEO PHARMA AS (DK) | 2004-06-23 | — | — | EP | disclosed |
| US-6313174-B1 | FOR THERAPY AND PROPHYLAXIS OF ASTHMA, ALLERGY, RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, GOUT, ATHEROSCLEROSIS, CHRONIC INFLAMMATORY BOWEL DISEASE, PROLIFERATIVE AND INFLAMMATORY SKIN DISORDERS | Leo Pharmaceutical Products Ltd.A/S/ (Løvens kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-11-06 | — | — | US | disclosed |
| EP-0966424-A1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998032730-A1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1998-07-30 | — | — | WO | disclosed |