Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3999412 | 0.87 | GSK3B (0.52) | GSK3BADORA2AADORA2BMEN1ALDH1A1 | |
| SCHEMBL4005322 | 0.84 | ADORA2A (0.49) | GSK3BADORA2AADORA2BMAOB | |
| SCHEMBL5904466 | 0.83 | HRH3 (0.43) | GSK3BADORA2AADORA2BMAOBMEN1 | |
| SCHEMBL3996832 | 0.82 | ADORA2A (0.56) | GSK3BADORA2AADORA2BMAOBALDH1A1 | |
| SCHEMBL3997939 | 0.82 | MAOB (0.45) | GSK3BADORA2AADORA2BMAOBMEN1 | |
| SCHEMBL4000348 | 0.82 | MAOB (0.46) | GSK3BADORA2AADORA2BMAOBMEN1 | |
| SCHEMBL3999451 | 0.82 | ADORA2A (0.46) | GSK3BADORA2AADORA2BMAOBMEN1 | |
| SCHEMBL4001758 | 0.82 | GSK3B (0.43) | GSK3B | |
| SCHEMBL7491544 | 0.82 | ADORA2A (0.41) | GSK3BADORA2AADORA2BMAOBMEN1 | |
| SCHEMBL4001825 | 0.81 | ADORA2A (0.45) | GSK3BADORA2AADORA2BMAOBADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1315731-B1 | 2-PYRIDINYL-6,7,8,9-TETRAHYDROPYRIMIDO[1,2-A]PYRIMIDIN-4-ONE AND 7-PYRIDINYL-2,3-DIHYDROIMIDAZO[1,2-A]PYRIMIDIN-5(1H)ONE DERIVATIVES | SANOFI SYNTHELABO (FR) | 2004-06-16 | — | — | EP | claimed |