Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | GRIN2B | Q13224 | 12/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | FAAH | O00519 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27149310 | 0.93 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9AGRIN2BHTT | |
| SCHEMBL8764844 | 0.88 | HTT (0.60) | SMN1; SMN2NPC1RAB9AGRIN2BHTT | |
| SCHEMBL10153811 | 0.87 | GRIN2B (0.69) | SMN1; SMN2NPC1RAB9AGRIN2BHTT | |
| SCHEMBL15140566 | 0.87 | SMN1; SMN2 (0.72) | SMN1; SMN2NPC1RAB9AGRIN2BHTT | |
| SCHEMBL13519706 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9AGRIN2BHTT | |
| SCHEMBL13274303 | 0.85 | HTT (0.69) | SMN1; SMN2NPC1RAB9AGRIN2BHTT | |
| SCHEMBL458148 | 0.84 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9AGRIN2BHTT | |
| SCHEMBL21553751 | 0.84 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9AGRIN2BHTT | |
| SCHEMBL28978045 | 0.84 | HTT (0.68) | SMN1; SMN2NPC1RAB9AGRIN2BHTT | |
| SCHEMBL16399970 | 0.84 | HTT (0.56) | SMN1; SMN2NPC1RAB9AGRIN2BHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995018619-A9 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-10-21 | — | — | WO | disclosed |
| US-6117866-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-09-12 | — | — | US | disclosed |
| EP-0738150-A4 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0738150-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-10-23 | — | — | EP | disclosed |
| WO-1995018619-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-07-13 | — | — | WO | disclosed |