Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | GRIN2B | Q13224 | 11/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.52 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.52 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19658451 | 0.93 | SMN1; SMN2 (0.54) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL6654650 | 0.88 | SMN1; SMN2 (0.62) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL16399970 | 0.86 | HTT (0.56) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL7441282 | 0.85 | TPSAB1 (0.56) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL15140566 | 0.85 | SMN1; SMN2 (0.72) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL13519706 | 0.84 | SMN1; SMN2 (0.67) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL27149310 | 0.83 | SMN1; SMN2 (0.60) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL8765520 | 0.83 | SMN1; SMN2 (0.62) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL13274303 | 0.83 | HTT (0.69) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL1912329 | 0.83 | KMT2A (0.57) | HTTSMN1; SMN2NPC1RAB9AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625509-B1 | N-alkyl substituted piperidine-derivatives with neurokinin receptor antagonist activity | ZENECA LTD (GB) | 1997-07-30 | — | — | EP | disclosed |
| US-5521199-A | TREATMENT OF ASTHMA | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0625509-A1 | N-alkyl substituted piperidine-derivatives with neurokinin receptor antagonist activity | ZENECA LIMITED (GB) | 1994-11-23 | — | — | EP | disclosed |