Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.80 |
| ▸ | MMP13 | P45452 | 11/20 | 0.80 |
| ▸ | MMP9 | P14780 | 10/20 | 0.75 |
| ▸ | MMP1 | P03956 | 8/20 | 0.60 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.52 |
| ▸ | MMP7 | P09237 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP14 | P50281 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3941409 | 0.92 | ADAM17 (0.80) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL6659884 | 0.89 | ADAM17 (1.00) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL3947817 | 0.87 | ADAM17 (1.00) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL3949526 | 0.87 | ADAM17 (1.00) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL3938344 | 0.87 | ADAM17 (1.00) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6657039 | 0.86 | ADAM17 (0.80) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL3940267 | 0.85 | ADAM17 (1.00) | ADAM17MMP13MMP9MMP1MMP14 | |
| SCHEMBL7422448 | 0.81 | ADAM17 (0.78) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL6656781 | 0.81 | ADAM17 (0.80) | ADAM17MMP13MMP9MMP1MMP14 | |
| SCHEMBL6654489 | 0.81 | ADAM17 (1.00) | ADAM17MMP13MMP9MMP1MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | claimed |
| EP-1147080-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | disclosed |