Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7648 | 0.89 | MEN1 (0.44) | MEN1KMT2AL3MBTL1HTTTDP1 | |
| SCHEMBL2106 | 0.87 | MAPT (0.39) | LPAR1LPAR3EDNRBEDNRAMAPT | |
| SCHEMBL1166 | 0.87 | LPAR1 (0.47) | LPAR1LPAR3ALDH1A1EDNRBEDNRA | |
| SCHEMBL1651 | 0.79 | LPAR1 (0.39) | LPAR1LPAR3ALDH1A1EDNRBEDNRA | |
| SCHEMBL1579 | 0.79 | LPAR1 (0.39) | LPAR1LPAR3ALDH1A1LMNAABCC3 | |
| SCHEMBL2096 | 0.77 | MAPT (0.46) | MEN1KMT2AL3MBTL1HTTTDP1 | |
| SCHEMBL6665 | 0.77 | MEN1 (0.45) | MEN1KMT2AL3MBTL1HTTTDP1 | |
| SCHEMBL1733 | 0.77 | LPAR1 (0.37) | LPAR1LPAR3MAPTGAANPSR1 | |
| SCHEMBL2195 | 0.77 | LPAR1 (0.48) | MEN1KMT2AHTTTDP1LPAR1 | |
| SCHEMBL343959 | 0.76 | LPAR1 (0.68) | MEN1KMT2ALPAR1LPAR3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |