Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.39 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | EDNRB | P24530 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6655 | 0.89 | MEN1 (0.42) | MEN1KMT2AHTTL3MBTL1TDP1 | |
| SCHEMBL4407 | 0.81 | SMPD1 (0.42) | MAPT | |
| SCHEMBL6665 | 0.79 | MEN1 (0.45) | MEN1KMT2AHTTL3MBTL1TDP1 | |
| SCHEMBL343959 | 0.78 | LPAR1 (0.68) | MEN1KMT2ALPAR1LPAR3ALDH1A1 | |
| SCHEMBL2096 | 0.77 | MAPT (0.46) | MEN1KMT2AHTTL3MBTL1TDP1 | |
| SCHEMBL1406 | 0.76 | LPAR1 (0.40) | MEN1KMT2AHTTLPAR1LPAR3 | |
| SCHEMBL6984 | 0.76 | LPAR1 (0.44) | MEN1KMT2ALPAR1LPAR3ALDH1A1 | |
| SCHEMBL2106 | 0.76 | MAPT (0.39) | LPAR1LPAR3MAPTEDNRBEDNRA | |
| SCHEMBL1166 | 0.75 | LPAR1 (0.47) | LPAR1LPAR3ALDH1A1MAPTGAA | |
| SCHEMBL6364 | 0.72 | LPAR1 (0.42) | L3MBTL1LPAR1LPAR3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |