Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6656344 | 0.88 | TSHR (0.55) | KDM4EALDH1A1GAAMAPK1DRD2 | |
| SCHEMBL18669175 | 0.88 | KDM4E (0.60) | KDM4EALDH1A1GAAMAPK1DRD2 | |
| SCHEMBL18750640 | 0.86 | DRD2 (0.54) | KDM4EALDH1A1GAAMAPK1DRD2 | |
| SCHEMBL17149768 | 0.86 | KDM4E (0.52) | KDM4EALDH1A1GAAMAPK1DRD2 | |
| SCHEMBL2760007 | 0.86 | POLB (0.53) | POLBKDM4EALDH1A1DRD2DRD3 | |
| SCHEMBL6659424 | 0.84 | KDM4E (0.60) | KDM4EALDH1A1GAAMAPK1DRD2 | |
| SCHEMBL22809795 | 0.84 | KDM4E (0.58) | KDM4EALDH1A1GAAMAPK1DRD2 | |
| SCHEMBL34468977 | 0.83 | NPC1 (0.60) | POLBKDM4EALDH1A1TP53 | |
| SCHEMBL6300914 | 0.82 | HDAC2 (0.57) | KDM4EALDH1A1GAAMAPK1DRD2 | |
| SCHEMBL26096928 | 0.81 | NSD2 (0.57) | POLBKDM4EALDH1A1MAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1440966-A1 | Indole derivatives useful for the treatment of diseases | Pfizer Limited (GB) | 2004-07-28 | — | — | EP | disclosed |