Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | PRNP | P04156 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.58 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.51 |
| ▸ | SELE | P16581 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8412494 | 0.89 | NPSR1 (0.74) | MAPK1PRNPTSHRPPARGHTT | |
| SCHEMBL5230453 | 0.87 | MAPT (0.55) | MAPK1PRNPTSHRPPARGHTT | |
| SCHEMBL1447569 | 0.86 | PRNP (0.60) | MAPK1PRNPTSHRPPARGHTT | |
| SCHEMBL5212677 | 0.86 | RXFP1 (0.60) | MAPK1PRNPTSHRPPARGHTT | |
| SCHEMBL5034019 | 0.85 | ICAM1 (0.55) | MAPK1PRNPTSHRPPARGHTT | |
| SCHEMBL6196210 | 0.85 | RXFP1 (0.53) | MAPK1PRNPTSHRPPARGHTT | |
| SCHEMBL9920609 | 0.85 | MAPT (0.48) | MAPK1PRNPTSHRPPARGHTT | |
| SCHEMBL15910659 | 0.84 | L3MBTL1 (0.58) | MAPK1PRNPTSHRPPARGHTT | |
| SCHEMBL9433072 | 0.84 | PRNP (0.81) | MAPK1PRNPTSHRPPARGHTT | |
| SCHEMBL6653351 | 0.84 | L3MBTL1 (0.58) | MAPK1PRNPTSHRPPARGHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9145414-B2 | 1,2,4-triazine-6-carboxamide derivative | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2015-09-29 | — | — | US | disclosed |
| US-20140343038-A1 | 1,2,4-TRIAZINE-6-CARBOXAMIDE DERIVATIVE | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2014-11-20 | — | — | US | disclosed |
| EP-2762476-A1 | 1,2,4-TRIAZINE-6-CARBOXAMIDE DERIVATIVE | Taiho Pharmaceutical Co., Ltd. (JP) | 2014-08-06 | — | — | EP | disclosed |
| EP-0817635-B1 | USE OF THIAZEPINE, OXAZEPINE AND DIAZEPINE COUMPOUNDS FOR INHIBITING HIV, HERPESVIRUS AND SUPPRESSING THE IMMUNE SYSTEM | WARNER LAMBERT CO (US) | 2004-06-16 | — | — | EP | disclosed |
| EP-0749434-B1 | BENZOTHIOPHENE, BENZOFURAN AND INDOLETHIAZEPINONES, OXAZEPINONES AND DIAZEPINONES AS INHIBITORS OF CELL ADHESION AND AS INHIBITORS OF HIV | WARNER LAMBERT CO (US) | 1999-12-15 | — | — | EP | disclosed |
| EP-0817635-A1 | USE OF THIAZEPINE, OXAZEPINE AND DIAZEPINE COUMPOUNDS FOR INHIBITING HIV, HERPESVIRUS AND SUPPRESSING THE IMMUNE SYSTEM | WARNER-LAMBERT COMPANY LLC (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5703069-A | USING (THIA, OXA, OR DI)AZEPINONE COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1997-12-30 | — | — | US | disclosed |
| EP-0749434-A1 | BENZOTHIOPHENE, BENZOFURAN AND INDOLETHIAZEPINONES, OXAZEPINONES AND DIAZEPINONES AS INHIBITORS OF CELL ADHESION AND AS INHIBITORS OF HIV | WARNER-LAMBERT COMPANY (US) | 1996-12-27 | — | — | EP | disclosed |
| US-5565446-A | USEFUL IN TREATMENT OF INFLAMMATORY DISEASES | WARNER-LAMBERT COMPANY (US) | 1996-10-15 | — | — | US | disclosed |
| WO-1996029077-A1 | USE OF THIAZEPINE, OXAZEPINE AND DIAZEPINE COUMPOUNDS FOR INHIBITING HIV, HERPESVIRUS AND SUPPRESSING THE IMMUNE SYSTEM | WARNER-LAMBERT COMPANY (US) | 1996-09-26 | — | — | WO | disclosed |
| US-5489586-A | BENZOTHIOPHEN, BENZOFURAN AND INDOLE-THIAZEPINONES, OXAZEPINONES AND DIAZEPINONES | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |
| WO-1995024408-A1 | BENZOTHIOPHENE, BENZOFURAN AND INDOLETHIAZEPINONES, OXAZEPINONES AND DIAZEPINONES AS INHIBITORS OF CELL ADHESION AND AS INHIBITORS OF HIV | WARNER-LAMBERT COMPANY (US) | 1995-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343038-A1 | 1,2,4-TRIAZINE-6-CARBOXAMIDE DERIVATIVE | SYK, BTK, JAK2 | MAPK1 375/4885PRNP 4881/4885TSHR 828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.