Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 11/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 11/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 11/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 11/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 11/20 | 0.52 |
| ▸ | DRD2 | P14416 | 9/20 | 0.52 |
| ▸ | DRD4 | P21917 | 9/20 | 0.52 |
| ▸ | DRD3 | P35462 | 9/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30460612 | 1.00 | POLB (0.65) | POLBCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL14277003 | 0.86 | POLB (0.61) | POLBCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL17969134 | 0.83 | POLB (0.67) | POLBCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2954869 | 0.83 | HTR7 (0.53) | POLBDRD2DRD4DRD3 | |
| SCHEMBL5661091 | 0.83 | CHRM2 (0.67) | POLBCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL8556193 | 0.81 | POLB (0.65) | POLBCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL29525493 | 0.81 | POLB (0.65) | POLBCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL933584 | 0.81 | POLB (0.64) | POLBCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL29456062 | 0.81 | POLB (0.64) | POLBCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3785481 | 0.80 | POLB (0.58) | POLBCHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103974948-A | Substituted benzyl indazoles as BUB1 kinase inhibitors in the treatment of hyperproliferative diseases | Bayer Pharma AG | 2014-08-06 | — | — | CN | disclosed |
| CN-102239159-B | 7-piperidinoalkyl-3,4-dihydroquinolone derivative | TAISHO PHARMACEUTICAL CO LTD | 2014-06-25 | — | — | CN | disclosed |
| CN-101754761-B | Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agents | REVIVA PHARMACEUTICALS INC | 2014-06-18 | — | — | CN | disclosed |
| EP-1470126-A1 | N-SUBSTITUTED SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER INC. (US) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003064425-A1 | N-SUBSTITUTED SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER JAPAN INC. (JP) | 2003-08-07 | — | — | WO | disclosed |