Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.60 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 3/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD5 | P21918 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | CPS1 | P31327 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1095538 | 0.84 | ESR1 (0.65) | ESR1ESR2ABHD6DRD1NOTUM | |
| SCHEMBL4937667 | 0.84 | ESR1 (0.65) | ESR1ESR2ABHD6DRD1NOTUM | |
| SCHEMBL1094619 | 0.82 | ESR1 (0.62) | ESR1ESR2ABHD6DRD1NOTUM | |
| SCHEMBL1095554 | 0.81 | ESR1 (0.61) | ESR1ESR2ABHD6DRD1MTNR1B | |
| SCHEMBL1095164 | 0.81 | ESR1 (0.61) | ESR1ESR2ABHD6DRD1MTNR1B | |
| SCHEMBL1095121 | 0.81 | ESR1 (0.61) | ESR1ESR2ABHD6DRD1MTNR1B | |
| SCHEMBL2309023 | 0.77 | ESR1 (0.85) | ESR1ESR2ABHD6DRD1NOTUM | |
| SCHEMBL4551325 | 0.77 | ESR1 (0.55) | ESR1ESR2ABHD6DRD1NOTUM | |
| SCHEMBL3895230 | 0.75 | ESR1 (1.00) | ESR1ESR2ABHD6DRD1CA1 | |
| SCHEMBL31164691 | 0.75 | ESR1 (0.90) | ESR1ESR2ABHD6DRD1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411881-A4 | 5HT sb 2C /sb RECEPTOR MODULATORS | ARENA PHARM INC (US) | 2004-07-07 | — | — | EP | disclosed |
| EP-1411881-A2 | 5HT sb 2C /sb RECEPTOR MODULATORS | Arena Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003086306-A2 | 5HT2C RECEPTOR MODULATORS | ARENA PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |