Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.76 |
| ▸ | NAMPT | P43490 | 1/20 | 0.71 |
| ▸ | ABL1 | P00519 | 7/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11629326 | 0.85 | GAA (0.67) | TRPV1NAMPTABL1GAAKMT2A | |
| SCHEMBL2562031 | 0.84 | TRPV1 (0.75) | TRPV1NAMPTABL1KMT2AHTT | |
| SCHEMBL2914329 | 0.84 | TRPV1 (0.74) | TRPV1NAMPTABL1KMT2AHTT | |
| SCHEMBL20379842 | 0.84 | NAMPT (1.00) | NAMPT | |
| SCHEMBL23657648 | 0.83 | TRPV1 (0.78) | TRPV1NAMPTABL1KMT2AHTT | |
| Iodide SCHEMBL30758578 | 0.83 | TRPV1 (0.73) | TRPV1NAMPTABL1KMT2AHTT | |
| SCHEMBL5539768 | 0.83 | TRPV1 (0.78) | TRPV1NAMPTABL1KMT2AHTT | |
| SCHEMBL6122991 | 0.83 | ABL1 (0.76) | TRPV1ABL1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8298025 | 0.82 | GAA (0.79) | TRPV1GAAHTTNPC1RAB9A | |
| SCHEMBL677496 | 0.82 | TRPV1 (0.76) | TRPV1NAMPTABL1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432419-A1 | ARYL SUBSTITUTED PYRIDINECARBOXAMIDES AND THEIR USE AS SODIUM CHANNEL BLOCKERS | Euro-Celtique S.A. (LU) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003022276-A1 | ARYL SUBSTITUTED PYRIDINECARBOXAMIDES AND THEIR USE AS SODIUM CHANNEL BLOCKERS | EURO-CELTIQUE S.A. (LU) | 2003-03-20 | — | — | WO | disclosed |