SCHEMBL6657716

SCHEMBL6657716

CS(=O)(=O)c1ccc(-c2cc(C(F)(F)F)cnc2OCCO)cc1

nearest known ligand 0.80

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 17/20 0.80
PTGS1 P23219 8/20 0.70
PTGDR2 Q9Y5Y4 1/20 0.54
IDO1 P14902 1/20 0.52
MAP4K4 O95819 1/20 0.46
PIK3CA P42336 1/20 0.46
KCNH2 Q12809 1/20 0.46
MINK1 Q8N4C8 1/20 0.46
PI4KB Q9UBF8 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6659721 0.91 PTGS2 (0.77) PTGS2PTGS1PTGDR2IDO1
SCHEMBL6660838 0.90 PTGS2 (0.72) PTGS2PTGS1PTGDR2IDO1
SCHEMBL6659313 0.90 PTGS2 (0.80) PTGS2PTGS1PTGDR2
SCHEMBL6659736 0.89 PTGS2 (0.71) PTGS2PTGS1PTGDR2IDO1
SCHEMBL6659469 0.89 PTGS2 (0.71) PTGS2PTGS1PTGDR2IDO1
SCHEMBL6658868 0.87 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL6662773 0.87 PTGS2 (0.75) PTGS2PTGS1PTGDR2IDO1MAP4K4
SCHEMBL6659730 0.86 PTGS2 (0.73) PTGS2PTGS1PTGDR2IDO1MAP4K4
SCHEMBL8069301 0.85 PTGS2 (0.82) PTGS2PTGS1PTGDR2IDO1
SCHEMBL6659468 0.85 PTGS2 (0.80) PTGS2PTGS1PTGDR2IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1012142-B1 2,3,5-TRISUBSTITUTED PYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA INC (CA) 2004-08-11 EP claimed
EP-1012142-A1 2,3,5-TRISUBSTITUTED PYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 Merck Frosst Canada & Co. (CA) 2000-06-28 EP claimed
US-6046217-A TREATING AN INFLAMMATORY DISEASE SUSCEPTIBLE TO TREATMENT WITH A NON-STEROIDAL ANTI-INFLAMMATORY AGENT COMPRISING ADMINISTERING TO A PATIENT IN NEED OF SUCH TREATMENT A NONTOXIC 3-PHENYL SUBSTITUTED PYRIDINES MERCK FROSST CANADA & CO. (CA) 2000-04-04 US claimed
WO-1999014194-A1 2,3,5-TRISUBSTITUTED PYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA & CO. (CA) 1999-03-25 WO claimed
EP-1012142-B1 2,3,5-TRISUBSTITUTED PYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA INC (CA) 2004-08-11 EP disclosed
EP-1012142-A1 2,3,5-TRISUBSTITUTED PYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 Merck Frosst Canada & Co. (CA) 2000-06-28 EP disclosed
US-6046217-A TREATING AN INFLAMMATORY DISEASE SUSCEPTIBLE TO TREATMENT WITH A NON-STEROIDAL ANTI-INFLAMMATORY AGENT COMPRISING ADMINISTERING TO A PATIENT IN NEED OF SUCH TREATMENT A NONTOXIC 3-PHENYL SUBSTITUTED PYRIDINES MERCK FROSST CANADA & CO. (CA) 2000-04-04 US disclosed
WO-1999014194-A1 2,3,5-TRISUBSTITUTED PYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA & CO. (CA) 1999-03-25 WO disclosed