Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FUCA1 | P04066 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6659367 | 0.94 | FUCA1 (0.37) | FUCA1KCNH2KDM4EEPHX1S1PR1 | |
| SCHEMBL1517546 | 0.94 | FUCA1 (0.39) | FUCA1KCNH2KDM4EEPHX1S1PR1 | |
| SCHEMBL4537106 | 0.94 | FUCA1 (0.39) | FUCA1KCNH2KDM4EEPHX1S1PR1 | |
| SCHEMBL4537105 | 0.94 | FUCA1 (0.39) | FUCA1KCNH2KDM4EEPHX1S1PR1 | |
| Hydrochloric Acid SCHEMBL30222109 | 0.92 | FUCA1 (0.38) | FUCA1KCNH2KDM4EEPHX1S1PR1 | |
| SCHEMBL26879528 | 0.88 | FUCA1 (0.39) | FUCA1KCNH2KDM4E | |
| SCHEMBL6658436 | 0.87 | FUCA1 (0.33) | FUCA1KCNH2KDM4E | |
| SCHEMBL18886462 | 0.84 | FUCA1 (0.34) | FUCA1KCNH2KDM4E | |
| SCHEMBL8242207 | 0.84 | FUCA1 (0.34) | FUCA1KCNH2KDM4E | |
| SCHEMBL17287205 | 0.82 | FUCA1 (0.42) | FUCA1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1160267-B1 | CATALYST FOR OXIDATIVE POLYMERIZATION OF FLUOROPHENOL, METHOD OF OXIDATIVE POLYMERIZATION OF FLUOROPHENOL, AND POLY(OXYFLUOROPHENYLENE) DERIVATIVE | JAPAN SCIENCE & TECH CORP (JP) | 2004-08-04 | — | — | EP | disclosed |