Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5404652 | 0.87 | RIPK3 (0.41) | PDE1APDE1BPDE1CLMNAPDE5A | |
| SCHEMBL5405288 | 0.86 | SLC16A1 (0.47) | TP53MAPTPDE1APDE1BPDE1C | |
| SCHEMBL5407653 | 0.84 | TP53 (0.40) | TP53MAPTPDE1APDE1BPDE1C | |
| SCHEMBL5400727 | 0.84 | TP53 (0.39) | TP53MAPTPDE1APDE1BPDE1C | |
| SCHEMBL5417969 | 0.84 | MEN1 (0.39) | PDE1APDE1BPDE1CADORA2BKCNA5 | |
| SCHEMBL5405558 | 0.83 | SLC16A1 (0.47) | TP53MAPTPDE1APDE1BPDE1C | |
| SCHEMBL5399340 | 0.82 | PDE5A (0.37) | PDE1APDE1BPDE1CLMNAPDE5A | |
| SCHEMBL5405716 | 0.82 | TP53 (0.44) | TP53MAPTPDE1APDE1BPDE1C | |
| SCHEMBL5404004 | 0.81 | MAPT (0.40) | TP53MAPTPDE1APDE1BPDE1C | |
| SCHEMBL5399832 | 0.81 | PDE5A (0.37) | PDE1APDE1BPDE1CPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412355-A1 | NEW PYRAZOLO(3,4-D)PYRIMIDINES INHIBITING H. PYLORI INFECTIONS | AstraZeneca AB (SE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003002567-A1 | NEW PYRAZOLO[3,4-D]PYRIMIDINES INHIBITING H. PYLORI INFECTIONS | ASTRAZENECA AB (SE) | 2003-01-09 | — | — | WO | disclosed |