SCHEMBL6659614

SCHEMBL6659614

O=C(O)c1ccc(CO)c(Cl)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.61
EPHX2 P34913 2/20 0.51
NR1H4 Q96RI1 1/20 0.51
ACE2 Q9BYF1 3/20 0.49
NR4A2 P43354 2/20 0.49
SRD5A2 P31213 1/20 0.48
TTR P02766 1/20 0.47
MAPT P10636 2/20 0.46
ALDH1A1 P00352 1/20 0.46
NR4A1 P22736 1/20 0.45
NR4A3 Q92570 1/20 0.45
ALOX15 P16050 1/20 0.45
MRGPRX4 Q96LA9 1/20 0.44
NPC1 O15118 1/20 0.44
HPGD P15428 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
TP53 P04637 1/20 0.42
KDM4E B2RXH2 1/20 0.42
CA12 O43570 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7052993 0.85 TSHR (0.57) TSHREPHX2NR1H4NR4A2SRD5A2
SCHEMBL17198001 0.84 TSHR (0.61) TSHREPHX2NR1H4NR4A2SRD5A2
SCHEMBL16011692 0.84 TSHR (0.61) TSHREPHX2ACE2NR4A2SRD5A2
SCHEMBL4837416 0.82 TSHR (0.59) TSHREPHX2NR1H4NR4A2SRD5A2
SCHEMBL2259867 0.82 TSHR (0.59) TSHREPHX2NR1H4ACE2NR4A2
SCHEMBL1237689 0.81 ACE2 (0.53) TSHRACE2SRD5A2MAPTALDH1A1
SCHEMBL29654186 0.81 ACE2 (0.53) TSHRACE2SRD5A2MAPTALDH1A1
Hydrochloric Acid SCHEMBL4698595 0.81 TSHR (0.57) TSHREPHX2NR1H4NR4A2SRD5A2
SCHEMBL25221325 0.79 TSHR (0.55) TSHREPHX2NR1H4NR4A2SRD5A2
SCHEMBL12438197 0.79 KDM4E (0.50) TSHREPHX2NR1H4ACE2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021037090-A1 NAPHTHYLAMINE COMPOUND AND BIOLOGICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF 河南省锐达医药科技有限公司 2021-03-04 WO disclosed
WO-2014063199-A1 ORGANIC COMPOUNDS AKAAL PHARMA PTY LTD (AU) 2014-05-01 WO disclosed
CN-103517910-A Morpholine-spirocyclic piperidine amides as modulators of ion channels VERTEX PHARMA 2014-01-15 CN disclosed
CN-101679287-B Nicotinic acetylcholine receptor modulators SIENA BIOTECH SPA 2013-03-27 CN disclosed
EP-0987122-B1 THERMAL RECORDING MATERIAL ASAHI DENKA KOGYO KK (JP) 2004-08-04 EP disclosed
US-6432875-B1 LOW MOLECULAR WEIGHT POLYESTER ASAHI DENKA KOGYO K.K. (JP) 2002-08-13 US disclosed
EP-0987122-A1 THERMAL RECORDING MATERIAL ASAHI DENKA KOGYO KABUSHIKI KAISHA (JP) 2000-03-22 EP disclosed