Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.43 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6659614 | 0.85 | TSHR (0.61) | TSHREPHX2NR1H4NR4A2SRD5A2 | |
| SCHEMBL25221325 | 0.84 | TSHR (0.55) | TSHREPHX2NR1H4NR4A2SRD5A2 | |
| SCHEMBL4810977 | 0.84 | PKM (0.47) | EPHX2NR1H4ALDH1A1MAPTMRGPRX4 | |
| SCHEMBL14037607 | 0.84 | TSHR (0.55) | TSHREPHX2NR1H4NR4A2SRD5A2 | |
| SCHEMBL9185167 | 0.84 | TSHR (0.55) | TSHREPHX2NR1H4NR4A2SRD5A2 | |
| SCHEMBL27885537 | 0.82 | TSHR (0.44) | TSHRSRD5A2ALDH1A1MAPTRARA | |
| Hydrochloric Acid SCHEMBL3656362 | 0.82 | TSHR (0.53) | TSHREPHX2NR1H4NR4A2SRD5A2 | |
| SCHEMBL17198001 | 0.81 | TSHR (0.61) | TSHREPHX2NR1H4NR4A2SRD5A2 | |
| SCHEMBL15660720 | 0.81 | RARB (0.54) | TSHREPHX2NR1H4ALDH1A1MAPT | |
| SCHEMBL8293311 | 0.80 | TSHR (0.50) | TSHREPHX2NR1H4NR4A2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4234552-A2 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | Raze Therapeutics, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| EP-0791590-B1 | Benzothiophenes, and formulations and methods using same | LILLY CO ELI (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6432982-B1 | TREATING POST-MENOPAUSAL WOMEN HAVING OSTEOPOROSIS, CARDIOVASCULAR DISORDERS AND ESTROGEN-DEPENDENT CANCER; RESTENOSIS INHIBITION; ENDOMETRIOSIS | ELI LILLY AND COMPANY | 2002-08-13 | — | — | US | disclosed |
| WO-1997030985-A1 | BENZOTHIOPHENES, AND FORMULATIONS AND METHODS, USING SAME | ELI LILLY AND COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |
| EP-0791590-A1 | Benzothiophenes, and formulations and methods using same | ELI LILLY AND COMPANY (US) | 1997-08-27 | — | — | EP | disclosed |