Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | FABP7 | O15540 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2775671 | 0.86 | MTNR1A (0.42) | MTNR1AMTNR1BPLAUFABP7FABP5 | |
| SCHEMBL878023 | 0.81 | MTNR1A (0.46) | MTNR1AMTNR1BPLAUFABP7FABP5 | |
| SCHEMBL30612403 | 0.80 | MTNR1A (0.53) | MTNR1AMTNR1BPLAUFABP7FABP5 | |
| SCHEMBL9415738 | 0.80 | MTNR1A (0.45) | MTNR1AMTNR1BPLAUFABP7FABP5 | |
| SCHEMBL13456262 | 0.80 | PLAU (0.47) | MTNR1AMTNR1BPLAUFABP7FABP5 | |
| SCHEMBL18714043 | 0.77 | MTNR1A (0.46) | MTNR1AMTNR1BPLAUFABP7FABP5 | |
| SCHEMBL16691724 | 0.76 | MTNR1A (0.45) | MTNR1AMTNR1BPLAUFABP7FABP5 | |
| SCHEMBL20476247 | 0.76 | BCHE (0.47) | MTNR1AMTNR1BPLAUFABP7FABP5 | |
| SCHEMBL20476252 | 0.76 | MTNR1A (0.49) | MTNR1AMTNR1BPLAUFABP7FABP5 | |
| SCHEMBL11555929 | 0.76 | PLAU (0.46) | MTNR1AMTNR1BPLAUANPEPIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444207-A2 | SUBSTITUTED PYRAZOLYL-COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003024935-A2 | SUBSTITUTED PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-03-27 | — | — | WO | disclosed |