Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6659927 | 0.91 | CYP11B2 (0.56) | CYP11B1CYP11B2CYP19A1NR3C1NPC1 | |
| SCHEMBL6846182 | 0.87 | CYP11B2 (0.54) | CYP11B1CYP11B2CYP19A1NPC1TP53 | |
| SCHEMBL6840530 | 0.81 | CYP11B2 (0.56) | CYP11B1CYP11B2CYP19A1FGFR1FGFR2 | |
| SCHEMBL6846125 | 0.81 | CYP11B2 (0.59) | CYP11B1CYP11B2CYP19A1FGFR1NTSR1 | |
| SCHEMBL6840527 | 0.81 | S1PR1 (0.47) | CYP11B1CYP11B2CYP19A1NR3C1S1PR1 | |
| SCHEMBL6656915 | 0.81 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP19A1NR3C1GABRG2 | |
| SCHEMBL6655119 | 0.80 | CYP11B2 (0.51) | CYP11B1CYP11B2CYP19A1NR3C1FGFR1 | |
| SCHEMBL6656508 | 0.80 | CYP11B2 (0.53) | CYP11B1CYP11B2CYP19A1NPC1RAB9A | |
| SCHEMBL6661401 | 0.80 | CYP11B1 (0.49) | CYP11B1CYP11B2CYP19A1NPC1RAB9A | |
| SCHEMBL6657585 | 0.78 | CYP11B2 (0.48) | CYP11B1CYP11B2CYP19A1NTSR1CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040236110-A1 | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors | BAYER PHARMACEUTICALS CORPORATION | 2004-11-25 | — | — | US | disclosed |
| EP-1432698-A2 | SUBSTITUTED 3-PYRIDYL INDOLES AND INDAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027094-A2 | SUBSTITUTED 3-PYRIDYL INDOLES AND INDAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236110-A1 | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors | CYP17A1, IDO1, CYP21A2 | CYP11B1 30/4885CYP11B2 53/4885CYP19A1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.