Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3520478 | 0.80 | ATM (0.38) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL28576366 | 0.80 | MAPT (0.41) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL9159521 | 0.80 | MAPT (0.37) | MAPTALDH1A1KMT2AMEN1POLB | |
| Hydrochloric Acid SCHEMBL29143517 | 0.78 | MAPT (0.36) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL29012480 | 0.77 | MAPT (0.39) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL10502356 | 0.77 | ATM (0.39) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL22410854 | 0.77 | MAPT (0.36) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL29012467 | 0.77 | MAPT (0.36) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL31490531 | 0.76 | MAPT (0.35) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL8521194 | 0.76 | KMT2A (0.44) | MAPTALDH1A1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441722-A2 | MODULATORS OF KCNQ POTASSIUM CHANNELS AND USE THEREOF IN TREATING MIGRAINE AND MECHANISTICALLY RELATED DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2002072088-A2 | MODULATORS OF KCNQ POTASSIUM CHANNELS AND USE THEREOF IN TREATING MIGRAINE AND MECHANISTICALLY RELATED DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-09-19 | — | — | WO | disclosed |