Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502356 | 0.85 | ATM (0.39) | ATMMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL28058464 | 0.80 | NLRP3 (0.43) | ATMMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL28041004 | 0.80 | CTSV (0.37) | ATMMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL28576366 | 0.80 | MAPT (0.41) | ATMMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL6660995 | 0.80 | MAPT (0.37) | ATMMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL9159521 | 0.80 | MAPT (0.37) | ATMMAPTKMT2AALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL29143517 | 0.78 | MAPT (0.36) | ATMMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL29012467 | 0.77 | MAPT (0.36) | ATMMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL22410854 | 0.77 | MAPT (0.36) | ATMMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL29012480 | 0.77 | MAPT (0.39) | ATMMAPTKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119080627-A | Synthesis method of roxburgh Bei Kao shake | 江苏慧聚药业股份有限公司 | 2024-12-06 | — | — | CN | claimed |
| EP-0099766-B1 | 1-3-DIHYDRO 4-(1-HYDROXY-2-AMINO-ETHYL)-2H-INDOL-2-ONE DERIVATIVES, THEIR SALTS, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1986-04-09 | — | — | EP | claimed |
| EP-0099766-A1 | 1-3-Dihydro 4-(1-hydroxy-2-amino-ethyl)-2H-indol-2-one derivatives, their salts, process for their preparation, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1984-02-01 | — | — | EP | claimed |
| CN-115915942-A | Selective herbicides based on substituted isoxazoline carboxamides and mefenpyr-diethyl | 拜耳公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115666246-A | Selective herbicides based on substituted isoxazoline carboxamides and oxadiazons | 拜耳公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-115666244-A | Selective herbicides based on substituted isoxazoline carboxamides and cloquintocet-mexyl | 拜耳公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-108440378-B | Preparation method of iodine-hydrogen peroxide promoted 3-amino-2-indolone derivative at room temperature | 宁波大学 | 2021-03-12 | — | — | CN | disclosed |
| CN-108409630-B | Preparation method of 3-hydroxy-2-indolone derivative in aqueous phase | 宁波大学 | 2021-01-15 | — | — | CN | disclosed |
| CN-107686460-B | Preparation method of 3-substituted-3-hydroxy-2-indolone compound | 宁波大学 | 2020-06-12 | — | — | CN | disclosed |
| CN-107200705-B | A kind of preparation method of 3- nitro -2- indolone derivatives | 宁波大学 | 2019-09-13 | — | — | CN | disclosed |
| CN-108409630-A | preparation method of 3-hydroxy-2-indolone derivative in aqueous phase | 宁波大学 | 2018-08-17 | — | — | CN | disclosed |
| EP-1181275-A1 | THIO-OXINDOLE DERIVATIVES | American Home Products Corporation (US) | 2002-02-27 | — | — | EP | disclosed |
| EP-1175398-A1 | INDOLINE DERIVATIVES AS PROGESTERONE ANTAGONISTS | American Home Products Corporation (US) | 2002-01-30 | — | — | EP | disclosed |
| EP-1173212-A1 | CONTRACEPTIVE COMPOSITIONS CONTANING INDOLONE DERIVATIVES AND PROGESTATIONAL AGENTS | American Home Products Corporation (US) | 2002-01-23 | — | — | EP | disclosed |
| CN-1311775-A | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN INC (US) | 2001-09-05 | — | — | CN | disclosed |
| WO-2000066555-A1 | THIO-OXINDOLE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-09 | — | — | WO | disclosed |
| WO-2000066167-A1 | CONTRACEPTIVE COMPOSITIONS CONTAINING INDOLINE DERIVATIVES AND PROGESTATIONAL AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-09 | — | — | WO | disclosed |
| WO-2000066556-A1 | INDOLINE DERIVATIVES AS PROGESTERONE ANTAGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-09 | — | — | WO | disclosed |
| EP-0099766-B1 | 1-3-DIHYDRO 4-(1-HYDROXY-2-AMINO-ETHYL)-2H-INDOL-2-ONE DERIVATIVES, THEIR SALTS, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1986-04-09 | — | — | EP | disclosed |
| EP-0099766-A1 | 1-3-Dihydro 4-(1-hydroxy-2-amino-ethyl)-2H-indol-2-one derivatives, their salts, process for their preparation, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1984-02-01 | — | — | EP | disclosed |