SCHEMBL6661004

SCHEMBL6661004

NC(=O)c1nn(-c2ccc(S(N)(=O)=O)cc2)c2c1CCc1c-2cnn1Cc1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CCNA2 P20248 16/20 0.59
CDK2 P24941 16/20 0.59
CCNA1 P78396 16/20 0.59
IKBKB O14920 1/20 0.59
PTGS2 P35354 3/20 0.46
PTGS1 P23219 2/20 0.46
AURKA O14965 1/20 0.46
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA4 P22748 1/20 0.42
CA9 Q16790 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6795570 0.91 CCNA2 (0.59) CCNA2CDK2CCNA1IKBKBAURKA
SCHEMBL6787577 0.90 CCNA2 (0.47) CCNA2CDK2CCNA1IKBKBPTGS2
SCHEMBL6634331 0.88 CCNA2 (0.49) CCNA2CDK2CCNA1IKBKBCA1
SCHEMBL6662893 0.85 CCNA2 (0.56) CCNA2CDK2CCNA1IKBKBPTGS2
SCHEMBL6792450 0.80 CCNA2 (0.50) CCNA2CDK2CCNA1PTGS2PTGS1
SCHEMBL6792645 0.77 CCNA2 (0.54) CCNA2CDK2CCNA1
SCHEMBL5227494 0.75 CCNA2 (1.00) CCNA2CDK2CCNA1IKBKB
SCHEMBL5336472 0.74 IKBKB (0.52) CCNA2CDK2CCNA1IKBKBPTGS2
SCHEMBL6660064 0.74 CA9 (0.50) CCNA2CDK2CCNA1IKBKBPTGS2
SCHEMBL6665468 0.74 CCNA2 (0.72) CCNA2CDK2CCNA1IKBKBPTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1476431-A1 TRICYCLIC PYRAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION Pharmacia Corporation (US) 2004-11-17 EP claimed
WO-2003070706-A1 TRICYCLIC PYRAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION PHARMACIA CORPORATION (US) 2003-08-28 WO claimed
EP-1476431-A1 TRICYCLIC PYRAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION Pharmacia Corporation (US) 2004-11-17 EP disclosed
WO-2003070706-A1 TRICYCLIC PYRAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION PHARMACIA CORPORATION (US) 2003-08-28 WO disclosed