Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 8/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6655586 | 0.88 | PTPN11 (0.41) | THRATHRBPTPN11PTPN1HDAC8 | |
| SCHEMBL6656108 | 0.87 | PTPN11 (0.43) | PTPN11PTPN1HDAC8PDK2 | |
| SCHEMBL6657963 | 0.85 | PTPN11 (0.47) | PTPN11PTPN1HDAC8SOAT1 | |
| SCHEMBL6675268 | 0.85 | PTPN11 (0.47) | PTPN11PTPN1HDAC8SOAT1 | |
| SCHEMBL6656876 | 0.85 | PTPN11 (0.47) | PTPN11PTPN1HDAC8SOAT1 | |
| SCHEMBL6655589 | 0.84 | PTPN11 (0.38) | THRATHRBPTPN11PDK2CYP3A4 | |
| SCHEMBL6659332 | 0.81 | PTPN11 (0.41) | PTPN11PTPN1PDK2 | |
| SCHEMBL6661829 | 0.79 | PTPN11 (0.45) | PTPN11PTPN1HDAC8SOAT1 | |
| SCHEMBL6659101 | 0.79 | PTPN11 (0.39) | PTPN11HDAC8PDK2 | |
| SCHEMBL6656977 | 0.79 | PTPN11 (0.41) | PTPN11PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1160233-B1 | Novel terphenyl compounds | SHARP KK (JP) | 2004-07-21 | — | — | EP | claimed |
| EP-1160233-A2 | Novel terphenyl compounds | SHARP KABUSHIKI KAISHA (JP) | 2001-12-05 | — | — | EP | claimed |
| EP-1160233-B1 | Novel terphenyl compounds | SHARP KK (JP) | 2004-07-21 | — | — | EP | disclosed |
| EP-1160233-A2 | Novel terphenyl compounds | SHARP KABUSHIKI KAISHA (JP) | 2001-12-05 | — | — | EP | disclosed |