Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 5/20 | 0.45 |
| ▸ | RARB | P10826 | 3/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6657212 | 0.94 | PTPN11 (0.44) | PTPN11RARBPTPN1HDAC8TP53 | |
| SCHEMBL6675268 | 0.94 | PTPN11 (0.47) | PTPN11RARBPTPN1HDAC8TP53 | |
| SCHEMBL6656876 | 0.94 | PTPN11 (0.47) | PTPN11RARBPTPN1HDAC8TP53 | |
| SCHEMBL6657963 | 0.94 | PTPN11 (0.47) | PTPN11RARBPTPN1HDAC8TP53 | |
| SCHEMBL6661830 | 0.85 | PTPN11 (0.43) | PTPN11TSHRPLA2G4B | |
| SCHEMBL6659332 | 0.85 | PTPN11 (0.41) | PTPN11RARBPTPN1TP53TSHR | |
| SCHEMBL6656977 | 0.83 | PTPN11 (0.41) | PTPN11RARBTP53TSHR | |
| SCHEMBL6656108 | 0.83 | PTPN11 (0.43) | PTPN11RARBPTPN1HDAC8 | |
| SCHEMBL6655586 | 0.82 | PTPN11 (0.41) | PTPN11PTPN1HDAC8 | |
| SCHEMBL6661434 | 0.79 | THRA (0.40) | PTPN11PTPN1HDAC8SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1160233-B1 | Novel terphenyl compounds | SHARP KK (JP) | 2004-07-21 | — | — | EP | claimed |
| EP-1160233-A2 | Novel terphenyl compounds | SHARP KABUSHIKI KAISHA (JP) | 2001-12-05 | — | — | EP | claimed |
| EP-1160233-B1 | Novel terphenyl compounds | SHARP KK (JP) | 2004-07-21 | — | — | EP | disclosed |
| EP-1160233-A2 | Novel terphenyl compounds | SHARP KABUSHIKI KAISHA (JP) | 2001-12-05 | — | — | EP | disclosed |