Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28498330 | 0.97 | KDM4E (0.46) | KDM4ETHRBRECQLNFKB1MAPT | |
| SCHEMBL31575739 | 0.86 | KDM4E (0.43) | KDM4ETHRBRECQLNFKB1MAPT | |
| SCHEMBL27690307 | 0.84 | KDM4E (0.46) | KDM4ETHRBRECQLNFKB1MAPT | |
| SCHEMBL24064958 | 0.83 | TGFBR1 (0.57) | KDM4ETHRBRECQLNFKB1MAPT | |
| SCHEMBL24837488 | 0.82 | KDM4E (0.36) | KDM4ETHRBRECQLNFKB1MAPT | |
| SCHEMBL6661692 | 0.80 | KDM4E (0.41) | KDM4ETHRBRECQLNFKB1MAPT | |
| SCHEMBL7523302 | 0.80 | KDM4E (0.43) | KDM4ETHRBRECQLNFKB1MAPT | |
| SCHEMBL1644974 | 0.78 | MAPT (0.42) | KDM4ETHRBRECQLNFKB1MAPT | |
| SCHEMBL14128838 | 0.77 | SLC1A2 (0.50) | KDM4EALOX15SMN1; SMN2ALDH1A1MTNR1A | |
| SCHEMBL143910 | 0.75 | KDM4E (0.48) | KDM4ETHRBRECQLNFKB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252575-B1 | 2-AMINO-2-PHENYLALKANOL DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | OROXCELL (FR) | 2012-12-19 | — | — | EP | disclosed |
| EP-2252575-A1 | 2-AMINO-2-PHENYLALKANOL DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Oroxcell (FR) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009112703-A1 | 2-AMINO-2-PHENYLALKANOL DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | OROXCELL (FR) | 2009-09-17 | — | — | WO | disclosed |