Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 19/20 | 0.71 |
| ▸ | CDK2 | P24941 | 19/20 | 0.71 |
| ▸ | CCNA1 | P78396 | 16/20 | 0.71 |
| ▸ | AURKA | O14965 | 13/20 | 0.71 |
| ▸ | IKBKB | O14920 | 1/20 | 0.57 |
| ▸ | PLK1 | P53350 | 3/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 4/20 | 0.47 |
| ▸ | CCND3 | P30281 | 4/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.47 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.47 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15300328 | 0.87 | CCNA2 (0.56) | CCNA2CDK2CCNA1AURKAIKBKB | |
| SCHEMBL15300318 | 0.84 | CCNA2 (0.53) | CCNA2CDK2CCNA1AURKAIKBKB | |
| SCHEMBL6665468 | 0.78 | CCNA2 (0.72) | CCNA2CDK2CCNA1AURKAIKBKB | |
| SCHEMBL3503440 | 0.78 | CCNA2 (0.65) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL5334053 | 0.77 | CCNA2 (0.62) | CCNA2CDK2CCNA1AURKAIKBKB | |
| SCHEMBL6794909 | 0.77 | CCNA2 (0.62) | CCNA2CDK2CCNA1AURKAIKBKB | |
| SCHEMBL6663541 | 0.77 | CCNA2 (0.65) | CCNA2CDK2CCNA1AURKAIKBKB | |
| SCHEMBL6791456 | 0.75 | CCNA2 (0.62) | CCNA2CDK2CCNA1AURKAIKBKB | |
| SCHEMBL5343708 | 0.73 | IKBKB (0.57) | CCNA2CDK2CCNA1AURKAIKBKB | |
| SCHEMBL5227494 | 0.73 | CCNA2 (1.00) | CCNA2CDK2CCNA1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636236-B1 | PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | claimed |
| EP-1476431-A1 | TRICYCLIC PYRAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2004-11-17 | — | — | EP | claimed |
| WO-2003070706-A1 | TRICYCLIC PYRAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-08-28 | — | — | WO | claimed |
| EP-1636236-B1 | PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | disclosed |
| EP-1476431-A1 | TRICYCLIC PYRAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003070706-A1 | TRICYCLIC PYRAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-08-28 | — | — | WO | disclosed |