Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 16/20 | 0.65 |
| ▸ | CDK2 | P24941 | 16/20 | 0.65 |
| ▸ | CCNA1 | P78396 | 16/20 | 0.65 |
| ▸ | IKBKB | O14920 | 1/20 | 0.65 |
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA4 | P22748 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6791456 | 0.83 | CCNA2 (0.62) | CCNA2CDK2CCNA1IKBKBAURKA | |
| SCHEMBL6794909 | 0.83 | CCNA2 (0.62) | CCNA2CDK2CCNA1IKBKBAURKA | |
| SCHEMBL5334053 | 0.81 | CCNA2 (0.62) | CCNA2CDK2CCNA1IKBKBAURKA | |
| SCHEMBL6665468 | 0.80 | CCNA2 (0.72) | CCNA2CDK2CCNA1IKBKBAURKA | |
| SCHEMBL5337003 | 0.79 | IKBKB (0.60) | CCNA2CDK2CCNA1IKBKB | |
| SCHEMBL5227494 | 0.79 | CCNA2 (1.00) | CCNA2CDK2CCNA1IKBKB | |
| SCHEMBL6659189 | 0.78 | CCNA2 (0.64) | CCNA2CDK2CCNA1IKBKBAURKA | |
| SCHEMBL5334241 | 0.78 | IKBKB (0.58) | CCNA2CDK2CCNA1IKBKB | |
| SCHEMBL5335359 | 0.78 | CCNA2 (0.58) | CCNA2CDK2CCNA1IKBKBAURKA | |
| SCHEMBL6661725 | 0.77 | CCNA2 (0.71) | CCNA2CDK2CCNA1IKBKBAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476431-A1 | TRICYCLIC PYRAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003070706-A1 | TRICYCLIC PYRAZOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-08-28 | — | — | WO | disclosed |